Recombinant Rat A-kinase anchor protein 12 (Akap12), partial

1. HSPA12B overexpression interacts with AKAP12 and downregulate TXNIP in diabetic rats following acute myocardial infarction. PMID: 28281242
2. SSeCKS play an important role in sciatic nerve fibers and neurons in spinal cord and dorsal root ganglion during inflammation. PMID: 24623461
3. Dynamic temporal changes in SSeCKS and Src expression may modulate angiogenesis and cerebral edema formation after focal cerebral ischemia. PMID: 21334414
4. Data show that SSeCKS can regulate LPS-induced TNF-alpha secretion through beta-1,4-GalT-I in rat primary astrocytes. PMID: 21573722
5. study delineates that SSeCKS may be important for host defenses in spinal inflammation and suggests a valuable molecular mechanism by which astrocytes modify neuronal viability during pathological states PMID: 20204485
6. Data show that SSeCKS is involved in the endothelial hyperpermeability induced by IL-1beta and TNF-alpha in inflammatory process. PMID: 20454828
7. Results suggest that SRC-suppressed C kinase substrate (SSeCKS) might be critical for the activation of astrocytes in neuropathic pain. PMID: 19937403
8. Platelet-activating factor can upregulate the expression of SSeCKS mRNA in a dose- and time-dependent manner in rat pulmonary microvascular endothelial cells. PMID: 20367900
9. SSeCKS upregulated in astrocytes in experimental autoimmune encephalomyelitis (EAE); understanding the mechanism of SSeCKS in the pathogenesis of EAE may contribute to the development of new therapeutic strategies against EAE and multiple sclerosis PMID: 20155814
10. signaling component essential for IL-17F-induced endothelial hyperpermeability PMID: 19577259
11. In long-term SSeCKS-reduced Schwann cells, cell morphology changed and myelin gene expression induced by cAMP was accelerated. Myelination was also enhanced in SSeCKS-suppressed Schwann cells co-culture with dorsal root ganglion (DRG). PMID: 19757038
12. a role in mitogen-induced cytoskeletal reorganization PMID: 12083796
13. SSeCKS functions in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling PMID: 12372401
14. alternately targeted anchoring protein isoforms provide a mechanism for genetic control of signaling specificity by AKAP12 PMID: 15496411
15. Transfected rat SSeCKS can suppress Src-induced oncogenesis in 3T3 cells by modulating gene expression downstream of Src kinase activity. PMID: 16638134
16. SSeCKS modulate endothelial cells adhesion and spreading by reorganization of the actin cytoskeleton. PMID: 17482576
17. SSeCKS is located downstream of PKC; SSeCKS and PKC are both necessary for LPS-induced stress fiber formation. PMID: 17551670
18. TNF-alpha induced rapid phosphorylation of protein kinase C substrates in C6 glioma cells, and upregulated SSeCKS expression in a time and concentration dependent manner. PMID: 17592532
19. SSeCKS could be detected in the whole brain of developing rat embryos and reached its peak at 1 week after birth, while during mature period, its level was decreasing PMID: 17873283
20. that SSeCKS is involved in the lipopolysaccharide-induced TNF-alpha expression in astrocytes mediated by protein kinase C PMID: 17873284
21. LPS could induce up-regulation of SSeCKS, and methylprednisolone sodium succinate inhibited the increase of SSeCKS mRNA induced by LPS. PMID: 18279585
22. participates in the adaptive response to peripheral nerve injury and may be associated with regeneration PMID: 18384053
23. SSeCKS modulate Schwann cells adhesion, spreading and migration by reorganization of the actin cytoskeleton. PMID: 18979197
24. These results indicate that Cited2 and Akap12 are silenced in radiation-induced osteosarcomas, and therefore are novel candidate tumor-suppressor genes of this tumor. PMID: 19825367

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KEGG: rno:83425

STRING: 10116.ENSRNOP00000057494

UniGene: Rn.122094