Recombinant Rat Calbindin(Calb1)

Code CSB-YP004432RA
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Source Yeast
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Code CSB-EP004432RA
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Source E.coli
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Code CSB-EP004432RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004432RA
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Source Baculovirus
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Code CSB-MP004432RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Calb1
Uniprot No. P07171
Alternative Names Calb1Calbindin; Calbindin D28; D-28K; Spot 35 protein; Vitamin D-dependent calcium-binding protein; avian-type
Species Rattus norvegicus (Rat)
Expression Region 2-261
Target Protein Sequence AESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELLQARKKA GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQELDINN ISTYKKNIMA LSDGGKLYRT DLALILSAGD N
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Gene References into Functions
  1. Calbindin D-28K does not appear to associate with any particular neuronal phenotype in the spinal dorsal horn, which may reflect that fact that most morphological types can be excitatory or inhibitory Its expression and distribution is unaffected by chronic constriction injury and increased excitatory synaptic drive to Cal+ neurons is unlikely to play a role in chronic constriction injury-induced central sensitization PMID: 26975894
  2. Negative calcium balance in aged ovariectomizrd animals is associated with downregulation of CaBP28K. PMID: 24378673
  3. Chronic high-salt diet increases expression of calbindin-D28k in renal tubules. PMID: 23199000
  4. The results obtained indicate that neocortical cells of adult rats submitted to early SI show a significant increase in the number of CB-ir neurons per cortical field, while selegiline treatment significantly reduces this parameter. PMID: 23253375
  5. The stress of maternal deprivation has a significant effect on calretinin and calbindin expression in both male and female rats, but affects glucocorticoid receptor levels only in males. PMID: 21835217
  6. midbrain dopamine release was efficiently controlled by a native fast calcium buffer, calbindin-D28k PMID: 22544312
  7. The distribution of Calb1 immunoreactivity was studied in the superior cervical ganglion, stellate ganglion and celiac ganglion from rats PMID: 22226503
  8. Increased Calbindin-D28k expression could relieve, neutralize and decrease intracellular Ca(2+) concentration to maintain calcium balance in idiopathic hypercalciuria. PMID: 18846343
  9. Expression levels of CB mRNA and protein may increase in the existing SNc DA neurons, which may compensate for the partial age dependent loss of CB+ DA neurons in the SNc. PMID: 19857553
  10. Jaundiced animals had a decrease in calbindin expression in the lateral vestibular nuclei and a paucity of calbindin-immunoreactive synaptic endings on the somata of Deiters' neurons. PMID: 12372637
  11. In the basolateral amygdala, a small percentage of calbindin-positive presynaptic terminals form synaptic contacts with interneurons; there are also calbindin-positive contacts with pyramidal cells. PMID: 12528187
  12. The distribution pattern of the CaBP28K-immunostained receptor neurons and their localized projection suggest the possibility that these neurons may express the same or functionally related pheromone receptor genes. PMID: 12834886
  13. The population of GluR1 and calbindin-containing interneurons is spared in malformed neocortex, but these cells sustain lasting decreases in their somatic expression of calbindin and alterations of dendritic structure. PMID: 12849753
  14. A mGluR agonist produced small increases in Calbindin immunoreactivity which was potentiated by a mGluR antagonist. This calbindin immunoreactivity increase was not due to de novo protein synthesis. PMID: 15143625
  15. Increasing Calbindin levels selectively in the dentate gyrus by gene transer disrupts mossy fiber-CA3 presynaptic function and impairs spatial cognition. PMID: 15318329
  16. thermodynamic and structural studies indicate that calcium binding by calbindin-D(28K) largely affects the local structure around the aromatic residues and the thermal stability of the protein; the changes in the secondary structure are insignificant PMID: 15464957
  17. These data suggest that calbindin-D28k equips hippocampal neurons with approximately 160 microM mobile, high-affinity Ca2+-binding sites that affect calcium signals. PMID: 15659591
  18. new RNA and protein syntheses are required for 1,25(OH)2D3-induced upregulation of CaBP28k PMID: 15922086
  19. The calbindin-regulated function of CaMKII and NeuroD in control of neuronal differentiation and neurite outgrowth is reported. PMID: 16278289
  20. These findings suggest a role for calbindin-D(28k) in the beta cell in modulating Ca(2+) influx via L-type voltage-dependent calcium channels. PMID: 16530828
  21. Therefore, the present study revealed that most of the Calb-IR neurons in the esophagus are nitrergic, and it suggested that the Calb-IR neurons might be primarily involved in interneuronal roles in the esophageal nervous system. PMID: 16600497
  22. The altered density of Calb1 immunoreactive cells and fibers in the lingual and laryngeal taste buds is a predominant feature of hypoxic adaptation PMID: 16977577
  23. Immature pyramidal neurons spontaneously secreted glutamate and that chronic blockade of either NMDA or AMPA receptors down-regulated the number of calbindin-D(28k)-positive pyramidal neurons without affecting neuronal survival. PMID: 17561837
  24. present data show that in rats M-type cells are numerous and widely distributed across the rat thalamus; however, calbindin is expressed only by a fraction, albeit a large one, of these cells. PMID: 17850982
  25. subsequent use of computational protein-protein docking protocols produce a model describing the interaction interface between calbindin-D28k and its target peptides PMID: 17880944
  26. decrease in hippocampal calbindin may be a major contributing factor underlying some of the plasticity changes that occur in epileptogenesis PMID: 18394865
  27. Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB(p65/p52) signaling pathway. PMID: 18703048
  28. There is a clear compartmentalization of calbindin-28 kDa and calretinin distribution in retinal ganglion cells. PMID: 18769561
  29. Presence of the disulfide bond between cysteines 94 and 100 in the Calb1 holoprotein indicates that there is predominantly no disulfide bond between these residues in the apo form. PMID: 19658395

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Protein Families Calbindin family
Database Links

KEGG: rno:83839

STRING: 10116.ENSRNOP00000010845

UniGene: Rn.3908

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