Product Details

Purity

>85% (SDS-PAGE)

Target Names

Gabra3

Uniprot No.

P20236

Alternative Names

Gabra3; Gabra-3; Gamma-aminobutyric acid receptor subunit alpha-3; GABA(A) receptor subunit alpha-3

Species

Rattus norvegicus (Rat)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Gene References into Functions

Sp4 functionally regulates the transcription of Gabra1 (GABAA alpha1) and Gabra2 (GABAA alpha2), but not Gabra3 (GABAA alpha3) subunit genes. PMID: 26469128
presence of alpha2 and alpha3 subunits during early development might make them more amenable to becoming sensitized by environmental stressors, whereas the relative paucity of alpha1 subunits at this age might limit the sensitization of this subunit. PMID: 22044189
clustering of GABA(A)R alpha2, alpha3, and GlyRs by gephyrin is mediated by distinct mechanisms at mixed glycinergic/GABAergic synapses. PMID: 21880742
Results describe the differential cellular distribution of alpha1, alpha2 and alpha3 GABA(A) receptor subunits in relation to striatopallidal (Str-GP) and pallidopallidal (GP-GP) synapses. PMID: 21219474
Distinct alpha subunit contributions create heterogeneity in developmental acceleration of IPSC decay in neocortex. PMID: 12433958
Developmental trends of subunits alpha1 and alpha3 intersected at P12. Switch in alpha3 and alpha1 during development may mediate different functional properties of GABA transmission. PMID: 14729731
a domain of four amino acids within the subunit mediates the distinct sensitivities to GABA;identified motifs contribute to a structure involved in the transduction of the binding signal rather than to the binding itself PMID: 15199051
These data demonstrate that the modulation of breathing via GABA(A) receptor activation will be determined by the overall balance of negative and positive neurosteroid modulators within respiratory nuclei. PMID: 16690709
Presence of persistent GABA(A)-mediated inhibitory modality in presympathetic paraventricular nucleus neurons, which plays major role in modulating their excitability and firing activity. PMID: 17495040
localized changes in GABA(A)R expression acting at highly specific points in the interconnected thalamocortical network lie at the heart of idiopathic generalized epilepsy PMID: 17630284
Our findings suggest that various combinations of GABA(A) alpha3-, theta- and epsilon-subunits may be assembled at a regional and developmental level in the brain. PMID: 19249336

Hide All

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA3 sub-subfamily

Tissue Specificity

Expressed in most brain regions.

Database Links

STRING: 10116.ENSRNOP00000050712

UniGene: Rn.10367

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-YP009142RA
MSDS	MSDS
Size	Pls inquire
Source	Yeast
Have Questions?	Leave a Message or Start an on-line Chat

Code	CSB-EP009142RA
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Have Questions?	Leave a Message or Start an on-line Chat

Code	CSB-EP009142RA-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions?	Leave a Message or Start an on-line Chat

Code	CSB-BP009142RA
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
Have Questions?	Leave a Message or Start an on-line Chat

Code	CSB-MP009142RA
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
Have Questions?	Leave a Message or Start an on-line Chat

Recombinant Rat Gamma-aminobutyric acid receptor subunit alpha-3 (Gabra3), partial

Product Details

Related Products

Customer Reviews and Q&A

Target Background

×CloseMessage