Recombinant Rat Glutamate receptor 1 (Gria1), partial

1. Following endoplasmic reticulum exit, the AMPA-type glutamate receptor GluA1 and neuroligin 1 undergo spatially restricted entry into the dendritic secretory pathway and accumulate in recycling endosomes (REs) located in dendrites and spines before reaching the plasma membrane. PMID: 28875935
2. Study describes a single trial, appetitive odor preference extended memory model following histone deacetylase (HDAC)inhibition, and demonstrates that this prolonged memory is related to GluA1 membrane expression in the dorsolateral and dorsomedial quadrants of the glomeruli, but not in the associated external plexiform layer. This extended memory is specific to the paired odor. PMID: 28916629
3. Presynaptic (CA3 pyramidal cell), but not postsynaptic (CA1 pyramidal cell), deletion of N-methyl-d-aspartate (NMDA)-type glutamate receptors eliminated the ketamine-induced enhancement of excitatory synaptic transmission in hippocampal slices and the antidepressant actions of ketamine PMID: 27965425
4. The relative gene expression of rostral ventral lateral medulla (RVLM) NMDA and AMPA glutamate-gated receptor subunits and protein concentration of select receptor subunits did not differ between young and aged rats, and there were no age-related differences in the expression of RVLM ionotropic GABAA and Gly receptors, or of protein concentration of select GABAA subunits. PMID: 28263869
5. Study visualized individual AMPAR endocytic events using a type of AMPAR subunit GluA1 fused to SEP (GluA1-SEP) and compared with endocytic events of SEP-tagged transferrin receptor (TfR-SEP). Constitutive endocytosis of AMPAR was not dependent on clathrin and dynamin in contrast to that of transferrin receptor. PMID: 28474392
6. In vivo data support an existence of a dynamic dopamine-acetylcholine balance in the striatum which actively modulates GluA1 AMPAR phosphorylation and trafficking. PMID: 27060412
7. these findings provide the first demonstration of the dynamic cross-modulation of GluA1 ubiquitination and phosphorylation, a process that is perturbed by Abeta, in regulating the membrane sorting decision that ultimately determines the number of AMPARs on the cell surface. PMID: 28377502
8. Study demonstrated that naltrexone-induced plasticity in excitatory synapses, via the transitory increase of GluA1 insertion at the postsynaptic density and GluA1-S845 phosphorylation, facilitates learning PMID: 26049209
9. AMPA-induced currents were recorded in the neurons using a whole-cell recording method. RESULTS: Four-hour exposure to AMPA significantly decreased the protein levels of TARP gamma-8 and GluA1 in the neurons at 17-18 DIV, but did not change the protein level of TARP gamma-8 in the neurons cultured at 7-8 DIV. PMID: 26725511
10. The 5-HT7 receptor-mediated phosphorylation of the GluA1 AMPA receptor provides a molecular mechanism consistent with the 5-HT7 receptor-mediated increase in AMPA receptor-mediated neurotransmission. PMID: 26773257
11. the phosphorylated ERK-pGluR1 cascade is involved in central sensitization of trigeminal spinal subnucleus caudalis nociceptive neurons. PMID: 27118769
12. The transmembrane domain of the GluA1 AMPAR is fully capable of tetramerization. PMID: 26839312
13. Data show that cyclin Y (CCNY) negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA receptor trafficking. PMID: 26220330
14. Knockdown of GluA1 prevents the effect, as does expression of a S845-phosphomutant of GluA1. PMID: 26055072
15. Arc/Arg3.1 in the NAc shell mediates the reconsolidation of morphine-associated context memory via up-regulating the level of membrane of GluR1 PMID: 25746394
16. Te results of this study showed that GluA1 concentrates away from the center of the synapse, extending at least 25 nm beyond the synaptic specialization in hippocampus. PMID: 25524891
17. markedly elevated protein levels of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 in the hippocampi of Sub mice PMID: 25796132
18. data suggest a negative feedback mechanism in retinal cells, that down-regulates transcription of genes encoding GluR1 regulatory proteins in response to glutamate exposure. PMID: 25792422
19. This study demonstrated that glur1 expression in rat auditory midbrain neurons. PMID: 25627107
20. Results suggest that hippocampal microglial activation modulates the level of GluR1 phosphorylation and might play a causal role in chronic stress-induced cognitive and LTP disturbances. PMID: 25472821
21. STIM2 promotes cAMP-dependent surface delivery of GluA1 through combined effects on exocytosis and endocytosis. PMID: 25609091
22. Intracellular Ca(2) and not the extracellular matrix determines surface dynamics of AMPA-type glutamate receptors on aspiny neurons. PMID: 25225098
23. reduced surface GluR1 expression may contribute to cognitive decline that occurs in normal aging; different pattern of surface GluR1 expression might be responsible for the individual differences in cognitive aging. PMID: 25697598
24. Increases in GluA1 S845 phosphorylation primarily occurred via PAC1 and VPAC2 receptor activation, whereas a reduction in GluA1 T840 phosphorylation was largely driven by PAC1 receptor activation. PMID: 25964356
25. A reduction in cholesterol leads to the activation of Cdc42 and the mobilization of GluA1-containing glutamate receptors (AMPARs) from Rab11-recycling endosomes into the synaptic membrane, leading to synaptic potentiation. PMID: 25753037
26. Neuronal stimulation and learning increased phosphorylation of GluA1, but the proportion was still low. PMID: 25533481
27. epigenetic up-regulation of BDNF by peripheral inflammation induces GluR1 phosphorylation at Ser-831 sites through activation of the phospholipase C-PKC signaling cascade, leading to the trafficking of GluA1 to pain-modulating neuronal synapses PMID: 24966334
28. Downregulation of GluR1 expression in dorsal horn cells prevents opioid-induced postoperative hyperalgesia. PMID: 25126703
29. miR-92a regulates translation and synaptic incorporation of new GluA1-containing AMPA receptors during activity blockade in the hippocampus. PMID: 25017011
30. AMPA receptor subunit GluR1 expression, trrafficking and long-term potentiation are suppressed in membrane-enriched hippocampus extract in response to aluminum exposure PMID: 24625397
31. Depletion of 5-HT in the lateral nucleus of the amygdala (LA) elevated fear-potentiated startle, with a parallel increase in GluR1 mRNA and protein expression. Low 5-HT in the LA may facilitate fear behavior through enhanced GluR-mediated mechanisms. PMID: 24002084
32. role of converging glutamate and dopamine inputs in regulating biochemical cascades upstream of GluA1 phosphorylation, focusing on the role of Ca(2+)-permeable AMPARs (CPARs), which lack the GluA2 AMPAR subunit PMID: 24133208
33. Data suggest that soluble ICAM-5 increases glutamatergic transmission and that post-synaptic changes, including increased phosphorylation and dendritic insertion of GluA1. PMID: 23844251
34. Glur1 is differentially regulated in hippocampus and cerebral cortex in this model of temporal lobe epilepsy. PMID: 23392471
35. These findings suggest that the AMPA receptor provides a PKG-sensitive phosphorylation site on GluR1-Ser845 in the NAc after repeated cocaine, thus contributing to behavioral alterations. PMID: 23583340
36. GluA1 phosphorylation in the lateral nucleus of the amygdala of fear-extinguished rats is a promising target for clinical treatment of aberrant fear-related disorders. PMID: 23974710
37. GluA1 AMPA receptor conductance can be increased by activated CaMKII or PKC PMID: 22373567
38. PKClambda is critical in GluA1 phosphorylation and synaptic incorporation during long-term potentiation. PMID: 23511975
39. AMPA and NMDA receptors are positively modulated by IL-1beta in a manner different from each other. PMID: 23537341
40. S-nitrosylation of GluA1 at C875 enhances S831 phosphorylation, facilitates the associated AMPA receptor conductance increase, and results in endocytosis by increasing receptor binding to the AP2 protein of the endocytotic machinery. PMID: 23277581
41. During long-term memory formation synaptic GluA1 receptors recruit CaMKIIalpha-BDNF-CREB pathways. PMID: 23160045
42. In response to activity, GluA1 and GluA2 receptor subunits exhibit reprogramming of the flip/flop exons. PMID: 23141062
43. Sex difference exists between female and male rats in hippocampal GluR1 and performance in the elevated plus maze. PMID: 21937801
44. This RAB-dependent GluA1 trafficking requires phosphorylation and activation of phosphoinositol-3-phosphate-5-kinase (PIKfyve) and the generation of PI(3,5)P(2). PMID: 22470488
45. Phosphorylation of AMPA receptor subunit GluA1 alters neuronal plasticity and temporal coding. PMID: 22567428
46. Ionotropic NMDA receptor subpopulations differentially regulate GluA1 phosphorylation, which may contribute to NMDA receptor-dependent synaptic plasticity. PMID: 21539895
47. Caspr1 is a regulator of the trafficking of AMPA receptors to synapses. PMID: 22223644
48. Hes-1 suppresses GluR1 promoter activity and decreases GluR1 expression through direct binding to the GluR1 promoter. PMID: 22302822
49. This study demonstrated that sub-chronic administration of B(a)P inhibits spatial learning and short-term memory, and increases Gria1 and Grin2a expression in the hippocampus. PMID: 22108330
50. These results suggest that low 5-hydroxytryptamine induces hyperexcitability of amygdala neurons by increasing GluR1 transcription. PMID: 21876464

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KEGG: rno:50592

UniGene: Rn.29971