Recombinant Rat Nuclear receptor subfamily 4 group A member 1 (Nr4a1)

1. Nur77 decreases ET-1 expression by suppressing NF-kappaB and p38 MAPK. PMID: 27765761
2. IGFBP-3 may trigger osteoarthritis by inducing chondrocyte apoptotis through nucleus-mitochondria translocation of Nur77. PMID: 26884829
3. Data indicate that orphan nuclear receptor Nur77 may be a sensor of oxidative stress and an inhibitor of vascular remodeling induced by low shear stress. PMID: 26498924
4. Results suggest that Nur77-targeted siRNA can inhibit autologous vein graft stenosis. PMID: 26276525
5. upregulation of Nur77 might be involved in Schwann cells differentiation and neurite elongation following sciatic nerve crush. PMID: 25957997
6. Data suggest that a dietary component, the medium-chain fatty acid decanoate, can down-regulate expression of Hsd3b2 in adrenals/ovaries in model of polycystic ovary syndrome; inhibition of recruitment of Nur77 to Hsd3b2 promoter is involved. PMID: 26465200
7. Results demonstrated that upregulated Nur77 may promote graft-infiltrating T lymphocyte apoptosis by translocating and inducing HtrA2/Omi release from mitochondria in acute rejection after cardiac transplantation. PMID: 26008781
8. Nur77 functionally interacts with NFATc3 and GATA4 and inhibits their transcriptional activities. PMID: 26195821
9. This study demonstrated the proapoptotic effect of Nur77 promotes cerebral cell apoptosis and induces early brain injury after experimental subarachnoid hemorrhage in rats. PMID: 24737679
10. The loss of Nr4a1 in immune cells appears to cause the increased kidney injury and reduced renal function observed in the Nr4a1(-/-) model. PMID: 24722447
11. Accompanied by the substantial decline in apoptosis inducer Nur77, myocardial ischemia/reperfusion induced cardiac dysfunction was manifested as cardiomyopathy and increased Reactive Oxygen Spieces. PMID: 24680679
12. we found that survivin is highly inducible following oxygen and glucose deprivation and is required for NR4A1 action PMID: 23663895
13. NR4A1 serves as an important point of negative feedback to minimize the excessive preantral follicle growth in hyperandrogenism. PMID: 23028064
14. PDGF-induced vascular smooth muscle cell proliferation was related to the Nur77 expression and CREB phosphorylation. Atorvastatin reduced the Nur77 expression and, at the same time, inhibited VSMC proliferation. PMID: 21505978
15. Stress affects cardiomyocytes by inducing NGFI-B mitochondrial translocation via serine phosphorylation, which in turn initiates mitochondrial-mediated apoptosis. PMID: 22128883
16. Stress could induce NGFI-B translocation from the nucleus to the mitochondria in cardiomyocytes, which activated the mitochondrial pathway of cell apoptosis. PMID: 22097717
17. Aetylation of Nrf2, p53 and Nur77 by CBP/p300 may constitute a novel similar regulatory mechanism for low-molecular-weight compounds with neurotrophic activities. PMID: 21908547
18. This study results showed that acute and repeated stress modulates Nur77 expression in BNST and suggest that Nur77 participates in extra-hypothalamic responses to stress. PMID: 21442465
19. Nur77 is a potential mechanism for improved skeletal muscle metabolism in response to exercise training. PMID: 21048074
20. Nur77 promotes VSMC proliferation PMID: 20411306
21. These results suggest that the expression of nur77, which is essential for the neuronal differentiation induced by dbcAMP (dibutyryl-cAMP ), is up-regulated via dbcAMP-induced acetylation of the Lys14 of histone H3 in PC12 cells. PMID: 20375114
22. NGFI-B induces cardiomyocyte apoptosis in restraint-stressed rats by mediating mitochondrial energy metabolism disorder PMID: 19412742
23. These findings suggest that NGFI-Bbeta plays an important role during the postmitotic differentiation of neuronal cells in the brain and retina. PMID: 19789410
24. Cells exposed to dibutyltindichloride plus a calcium chelator reduce the transcription of nur77. This confirms the role of calcium in induction of nur77. PMID: 12030839
25. The cell-type specific expression and LH induction of NGFI-B suggests a potential role of NGFI-B in the ovulatory process. PMID: 12770726
26. Nur77, which is regulated by a MAPK pathway activated via arrestin 2, modulates NK(1)R-mediated nonapoptotic programmed cell death PMID: 14769794
27. cadmium induces the expression of Nur77 family genes, leading to apoptosis in lung cells PMID: 15016657
28. characterization of rat orphan nuclear receptor NOR-1 LBD domain PMID: 15358368
29. Causal relationship between the rapid decline of aromatase mRNA and induction of orphan nuclear receptors NURR1 and NGFI-B expression, which concomitantly occur upon LH surge at the later stages of ovarian follicular development. PMID: 15486232
30. Expression of the NGFI-B gene in the rat pineal gland was found to exhibit robust circadian rhythm. NGFI-B mRNA and protein levels are elevated via activation of adrenergic receptors and expression also involves the AP-1 protein Fra-2 PMID: 15525348
31. In conclusion, our results suggest that cAMP-induced and Ca2+-induced processes may differentially regulate activity of Nur77 at the level of translocation of Nur77 protein from the cytoplasm into the nucleus. PMID: 15707695
32. expression of NOR-1 is differentially regulated in different brain regions in response to globally applied brain ischemia, but that hypoxia is not sufficient to induce its expression PMID: 16951544
33. Potential mediator of neuromuscular signaling in the control of metabolic gene expression. PMID: 17550977
34. The rapid induction of NGFI-B/Nur77 gene expression by LH/hCG in MA-10 cells appears to be mediated by both CREB and Jun family proteins through the cAMP-protein kinase A (PKA) pathway. PMID: 18163434
35. NUR77 and c-JUN have additive effects on the Star promoter. PMID: 18987158
36. The transcription factor C/EBPbeta can activate the Nur77 promoter through a functional cooperation between the p50 subunit of NF-kappaB. PMID: 18996961
37. Results suggest adrenergic stimulation as the most important stimulus for nur77 expression and point to a significant role for this transcription factor in adaptive changes in muscle after exercise and in insulin resistant states. PMID: 19447175

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KEGG: rno:79240

STRING: 10116.ENSRNOP00000010171

UniGene: Rn.10000