Recombinant Rat P2X purinoceptor 2 (P2rx2), partial

1. These data further reveal that the inner and outer ends of adjacent pore-lining helices come closer during opening, likely through a hinge-bending motion. PMID: 26808983
2. A trafficking mechanism for 5-HT3A receptor depends on a functional interaction with P2X2 receptor. PMID: 26843630
3. This study demonstrated that structural rearrangements of the linker region of the P2X2 receptor channel are induced not only by ligand binding but also by membrane potential change. PMID: 25172943
4. Our results suggest that each intersubunit ATP-binding signal is directly transmitted on the same subunit to the level of D315 via the domain that contributes K308 to the beta-14 strand. PMID: 24863932
5. Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking. PMID: 24515105
6. residues that are in close proximity within the transmembrane domain of rP2X2R PMID: 23936459
7. The presence of P2X2 receptors in the majority of noradrenergic cells of the area postrema implies a regulatory role for these receptors in neurons of area postrema. PMID: 22038573
8. Based on our immunofluorescence and immunoelectron microscopical studies we believe that both perigemmal and most all intragemmal nerve processes display P2X2-LIR. PMID: 22621423
9. High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism PMID: 22556417
10. The data of this study provided the first direct measures of P2X receptor mobility and show that P2X2 receptors are mobile ATP sensors, sampling more of the dendritic plasma membrane in response to ATP. PMID: 22090499
11. these findings indicate that ischemia and reperfusion induces changes in P2X2-ischemia and reperfusion enteric neurons that could result in alterations in intestinal motility. PMID: 21409380
12. In silico prediction of Gly72 and Glu167 as ATP-binding residues of the P2X2 receptor strongly supports the validity of homology docking. PMID: 21191044
13. The presence of P2X2R immunoreactivity in primarily orexigenic NPY/AgRP/GABA-containing neurons of the arcuate nucleus suggests that extracellular ATP has a regulatory action on this neuronal population located in a strategic position of the brain. PMID: 20736052
14. Myocardial ischemic injury induces an increase in expression of P2X(2/3) receptor colocalization with tyrosine hydroxylase and a hypersensitivity state of superior cervical ganglion neurons to ATP, which leads to increased sympathoexcitatory reflex. PMID: 20406659
15. Data demonstrate that expression of the P2X(2) receptor is present in inhibitory, intrinsic primary afferent, cholinergic secretomotor and vasomotor neurons. PMID: 20677337
16. Review illustrates how density-dependent changes in the P2X2 receptor pore properties have potential implications for physiological regulation by changing the local density of the channel at a synapse and in turn the dynamic properties of the synapse. PMID: 19752115
17. A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptor. PMID: 20308075
18. P2X(1) and P2X(2) receptor subunit involvement in neuronal reaction to axotomy; there is a correlation between purinergic receptor subunit up-regulation and survival of injured neurons. PMID: 12421608
19. The interactions that cause expression-dependent changes in P2X(2) receptor properties must involve domains proximal to position H397 PMID: 12604087
20. DHEA could be an endogenous modulator of P2X2-containing receptors thereby contributing to the facilitation of the detection and/or the transmission of nociceptive messages, in inflammatory pain where the P2X receptor signalling pathway is upregulated. PMID: 12844512
21. immunostaining of pancreas from streptozotocin-diabetic rats revealed P2X1, P2X2, P2Y1 and P2Y2 receptors are expressed in small blood vessels. PMID: 12850289
22. regulation of P2X(2) receptor gene expression in the cochlea is adaptive, with sustained loud sound promoting increased transcription and translation specifically at sites regulating hearing sensitivity and auditory neurotrans-mission PMID: 12858039
23. modulation of P2X2 receptor function, such as that evoked by acidification of the extracellular environment during hypercapnia, may contribute to the changes in activity of the ventral lateral medulla respiratory neurones PMID: 12878756
24. Presence of homomeric P2X2 receptor is demonstrated for the first time in rat otic neurons. PMID: 15081800
25. the pore properties of P2X2 channel are not static but change dynamically depending on the open channel density PMID: 15107474
26. Results identify a conserved motif in the cytoplasmic C termini of P2X2 and other P2X receptor subunits that is necessary for their surface expression. PMID: 15126501
27. Mapping of ATP-gated domains in the transmembrane segments of the P2X2 receptor. PMID: 15317863
28. C-terminal domain of P2X2 and the intracellular loop of beta GABAA subunits are required for the functional interaction between ATP- and GABA-gated channels PMID: 15456793
29. His120 and His213 sit close to each other across the interface between subunits and are likely to be key components of the zinc binding site in rat P2X2 receptors PMID: 15899882
30. results suggest that ATP mainly activates ionotropic P2X2 receptors, resulting in a [Ca2+]i increase dependent on [Ca2+]o in rat myenteric neurons PMID: 15905416
31. expression of P2X(2/3) receptors in superior cervical ganglion neurons during late embryonic and early post-natal development PMID: 15973739
32. The threefold symmetrical top view demonstrates the first visual evidence of the trimeric composition of the P2X receptor family. PMID: 16219297
33. P2X receptor signaling inhibits BDNF-mediated spiral ganglion neuron development in the neonatal rat cochlea. PMID: 17329369
34. P2X(2) receptors provide the potential for complex patterns of synaptic integration over a time scale of hundreds of milliseconds PMID: 17664346
35. Bladder inflammation sensitizes and increases P2X receptor expression and/or function for both pelvic and lumbar splanchnic pathways, which contribute, in part, to the hypersensitivity associated with cystitis. PMID: 17959738
36. the first transmembrane domain contributes little to the permeation properties of the P2X2 receptor PMID: 18048351
37. region in the vicinity of Asp(315) is at the plasma membrane interface & N-terminal portion of pre-second transmembrane domain (Arg(304)-Ile(314)) is important for the correct conformation of the receptor at the extracellular face of the membrane. PMID: 18616429
38. P2X(2) receptor together with P2X(3) receptor subtype plays an important role in cardiac vagal sensory nociceptors with a sensitivity to adenosine triphosphate (ATP). PMID: 19064335
39. The sparse, extended structure of the P2X(2) receptor indicates a loose assembly of subunits, which could be a basis for the activation-dependent pore dilation of P2X receptors. PMID: 19217397
40. P2X(2) transcripts and immunoreactivity were detected in approximately 50-60% of geniculate ganglion neuronal somata. PMID: 19266560
41. The results imply that the P2X2 gate is formed by residues Asn(333) to Thr(339) and that channel opening involves a counter-clockwise rotation and separation of the second transmembrane domain helices. PMID: 19906973

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KEGG: rno:114115

STRING: 10116.ENSRNOP00000053533

UniGene: Rn.88799