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Recombinant Rat Pancreas transcription factor 1 subunit alpha (Ptf1a)

Recombinant Rat Pancreas transcription factor 1 subunit alpha (Ptf1a)

Code	CSB-YP723736RA
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Yeast
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Code	CSB-EP723736RA
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
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Code	CSB-EP723736RA-B
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP723736RA
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP723736RA
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ptf1a

Uniprot No.

Q64305

Alternative Names

Ptf1a; Ptf1p48; Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; PTF1-p48

Species

Rattus norvegicus (Rat)

Expression Region

1-326

Target Protein Sequence

MDAVLLEHFP GALDTFPSSY FDEEDFFTDQ SSRDPLEDGD ELLGDEQAEV EFLSHQLHEY CYRDGACLLL QPAPSAAPHA LAPPPLGDPG EPEDSGSYCC DAGAPLGAFP YSPGSPPSCL AYPCTAVLSP GTRLRGLNGA AAAAAAAARR RRRVRSEAEL QQLRQAANVR ERRRMQSIND AFEGLRSHIP TLPYEKRLSK VDTLRLAIGY INFLSELVQA DLPLRGSGTG GCGGPGGSRH LGGDSPGNQA QKVIICHRGT RSPSPSDPDY GLPPLAGHSL SWADEKQLKE QNIIRTAKVW TPEDPRKLNS KSFDNIENEP PFEFVS

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.

Gene References into Functions

combined expression of key genes (Pdx1 and p48) involved in pancreatic development may be a promising approach to generate mature pancreatic exocrine cells. PMID: 17907943

Subcellular Location

Nucleus. Cytoplasm. Note=In the cytoplasm loses its ability to form the PTF1 complex.

Tissue Specificity

Exocrine pancreas-specific. Expressed in azaserine-induced pancreatic tumors (at protein level). Expressed in AR42J cells but not in ARIP, DSL6A, or DSL6B cells. Down-regulation is associated with the change of an azaserine-induced acinar cell carcinoma t

Database Links

KEGG: rno:117034

STRING: 10116.ENSRNOP00000022727

UniGene: Rn.10536

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