Recombinant Rat Receptor-type tyrosine-protein phosphatase S (Ptprs), partial

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

Ptprs

Uniprot No.

Alternative Names

Ptprs; Receptor-type tyrosine-protein phosphatase S; R-PTP-S; EC 3.1.3.48; Leukocyte common antigen-related protein-tyrosine phosphatase 2; LAR-PTP2; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma

Species

Rattus norvegicus (Rat)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.

Gene References into Functions

The present study found that astrocytes aberrantly and progressively expressed PTPsigma and LAR at the site of motor neuron degeneration in Tg ALS model rats with mutant SOD1. PMID: 28752900
Our study shows that modulation of PTPsigma is a potential therapeutic strategy for root avulsion. PMID: 26464223
PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. PMID: 25624497
results add a new layer of understanding to the critical role of PTPsigma in mediating the growth-inhibited state of neurons due to CSPGs within the injured adult spinal cord PMID: 25470046
PTPSigma is a neuronal membrane receptor and has a role in rat presynaptic function and cell-cell communication. PMID: 12110683
Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. PMID: 20139422

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone.

Protein Families

Protein-tyrosine phosphatase family, Receptor class 2A subfamily

Tissue Specificity

Detected in brain neocortex (at protein level). Detected in heart, testis and liver. Detected at lower levels in skeletal muscle, brain, spleen and kidney.

Database Links

KEGG: rno:25529

STRING: 10116.ENSRNOP00000065227

UniGene: Rn.91202

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Recombinant Rat Receptor-type tyrosine-protein phosphatase S (Ptprs), partial

Product Details

Customer Reviews and Q&A

Target Background

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