Recombinant Rat Serotonin N-acetyltransferase (Aanat)

1. identified one microRNA, miR-325-3p, as a potential candidate responsible for the down regulation of Aanat after survivors of hypoxic-ischemic brain damage PMID: 28502584
2. these and related results indicate both a major involvement of the N-end rule pathway in the control of rodent AANATs and substantial differences in the regulation of rodent and human AANATs that stem from differences in their N-terminal sequences. PMID: 27339900
3. Increased methylation and decreased gene expression in the Aanat gene after blast-related TBI in rats. PMID: 25594545
4. The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis PMID: 24877634
5. In rats, Aa-nat mRNAs were expressed and existed at high levels during nighttime. They gradually increased at puberty and decreased at 8 weeks of age. Nocturnal changes of Aa-nat mRNA levels in rat pineal gland from P4 to adults were strongly correlated. PMID: 23513468
6. Local modulation of melatonin synthesis by AANAT may be important for management of the balance between biliary proliferation/damage that is typical of cholangiopathies. PMID: 23080076
7. miR-483 suppresses Aanat mRNA levels during development and that the developmental decrease in miR-483 abundance promotes melatonin synthesis. PMID: 22908386
8. The expression of AANAT in epithelial cells of striated ducts in rat salivary glands. PMID: 21437622
9. Deletion analysis of N-terminus of AANAT identified the an amino acid leucine (L2) as the key residue that contributes to the proteasomal proteolysis of AANAT protein. PMID: 20210853
10. accumulation induced by pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide in vitro PMID: 11854096
11. inhibition of p38(MAPK), although having no effect on cAMP-mediated AA-NAT transcription, appears to increase AA-NAT activity either by increasing translation or by reducing degradation of the AA-NAT protein. PMID: 14617573
12. The rapidity of nocturnal AA-NAT induction depends on cAMP inducibility of the gene. Accordingly, cAMP produces a strong AA-NAT response in pineals obtained from rats housed under long photoperiods and a weak AA-NAT response under short photoperiods. PMID: 15046865
13. aa-nat mRNA increased between 60 and 180 min after the melatonin injection during the light period, while it did not significantly change during the dark period. PMID: 15193530
14. Effects of protein kinase C on protein stability and activity of rat AANAT were investigated. The results suggest that AANAT was phosphorylated at Thr29 by PKC activation through the alpha(1)-adrenergic receptor in rat pineal glands PMID: 15228600
15. AANAT mRNA degradation mediated by heterogeneous-muclear ribonucleoproteins hnRNP R, hnRNP Q, and hnRNP L is a key process in the regulation of its circadian oscillation. PMID: 15798208
16. Important role of proteasomal proteolysis in the adrenergic-mediated induction of aa-nat transcription through its effect on a protein repressor. PMID: 16099857
17. serotonin N-acetyltransferase regulation by bradykinin in rat pineal glands is affected by adenylyl cyclase VI PMID: 16166080
18. the effects of the proteasome inhibitors on NE-stimulated Aanat induction appear to be mediated by accumulation of a protein repressor [review] PMID: 16687309
19. E-box mutations enhanced ectopic expression establishing that the intronic Aanat E-box elements contribute to the gene's pineal specific expression. PMID: 17363136
20. These findings indicate that the transcriptions of Clock and NAT genes in the pineal gland not only show remarkably synchronous endogenous circadian rhythmic changes, but also respond to the ambient light signal in a reduced manner. PMID: 17364576

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KEGG: rno:25120

STRING: 10116.ENSRNOP00000015221

UniGene: Rn.88180