Recombinant Rat Synapsin-1 (Syn1)

1. The synapsin 1 in the insular cortex as a part of pathophysiological process that determines predisposition of Krushinsky-Molodkina rats to audiogenic seizures. PMID: 26923581
2. SUMOylation of synapsin Ia (SynIa) at K687 is necessary for SynIa function. Replacement of endogenous SynIa with a non-SUMOylatable mutant decreases the size of the releasable vesicle pool and impairs stimulated SV exocytosis. PMID: 26173895
3. Results suggest a mechanism of A2aR modulation of neurotransmitter release in cultured cells from medulla oblongata and suggest that protein kinase A mediates this modulation of neurotransmitter release via synapsin I phosphorylation PMID: 24912137
4. rSynI(1.0)-minCMV drives robust and neuron-specific transgene expression throughout the CNS and is therefore useful for viral vector-mediated neuron-specific gene delivery and generation of neuron-specific transgenic animals. PMID: 24361760
5. This study demonistrated that Increased activation of synapsin 1 in the amygdala of maternal separation rats. PMID: 24279756
6. O-GlcNAcylation of Thr-87 interferes with folding of the ALPS motif, providing a means for regulating the association of synapsin I with SVs as a mechanism contributing to synapsin I localization and RPSV generation. PMID: 24280219
7. The mean brightness of Syn1 per unit area of the dendritic tree of neurons changes over the estrous cycle, being approximately 35% lower at diestrus than at the remaining phases of the estrous cycle. PMID: 21948316
8. A hybrid peptide consisting of synapsin carboxyl domain fused with E coli enterotoxin B subunit up-regulates expression of anti-inflammatory cytokines and diminishes myelin basic protein-specific T-helper cell responses in lymph nodes. PMID: 22138356
9. Syn I phosphorylation at site 1 regulates synapse formation. PMID: 22045728
10. Data provide a complete molecular pathway (GR/Egr-1/MAPK/Syn-Ia/Ib) through which stress and glucocorticoids enhance the memory of stress-related events and highlight the function of synapsin-Ia/Ib as molecular effector of the behavioral effects of stress PMID: 20368707
11. Data show that Src-mediated tyrosine phosphorylation of synapsin I increases its binding to synaptic vesicles and actin, and increases the formation of synapsin dimers, which are both potentially involved in vesicle clustering. PMID: 20530578
12. Data suggest that integrin-linked kinase exerts pleiotropic actions by regulating pre- and postsynaptic neural plasticities in response to repeated cocaine exposure through PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. PMID: 19629758
13. Either C-terminal domain E or a peptide derived from domain C was necessary and sufficient to inhibit both dimerization and vesicle clustering, indicating the participation of both domains in these activities of synapsin I. PMID: 19922412
14. Seven days after fluid-percussion brain injury, synapsin I mRNA levels increase ipsilaterally and decrease contralaterally in the occipital cortex. PMID: 12184851
15. These results raise the possibility that Ser(603) on synapsin I is alternatively phosphorylated by p21-activated kinases, not only by CaMKII, in neuronal cells in response to some stimulants. PMID: 12237306
16. BEMAD methodology was validated by mapping three previously identified O-GlcNAc sites, as well as three novel sites, on Syn I. PMID: 12438562
17. multiple signaling pathways serve to allow synapsin's control of vesicle mobilization over different stimulus frequencies. PMID: 12691665
18. Time-dependent translocational changes of Synapsin I were investigated in regenerating axonal sprouts. PMID: 14612614
19. Calorimetric measurements of ATP binding to wild-type and mutant recombinant Synapsin I-ABC demonstrate that the multifunctional loop and a cross-tetramer contact are important for ATP binding PMID: 14688264
20. During the first postnatal week,synpsin 1 immunoreactive strongly concentrated in the Purkinje cell layer.By P14, synapsin 1 localized to many small puncta in the ML and to large clusters at mossy fiber rosettes in the glomerular layer. PMID: 15246689
21. glucose-dependent actions of ERK1/2 in beta-cells exerted on cytoplasmic proteins, includes synapsin I and participates in the overall glucose-induced insulin secretion. PMID: 15498890
22. In conclusion, this is the first evidence to show that PLD1 acts as an important regulator of neurite outgrowth in neural stem cell by promoting neuronal differentiation via increase of synapsin I expression. PMID: 15752728
23. findings show that synapsin I plays a central role in regulating the organization and dynamics of synaptic vesicles in growth cones and that this activity is modulated by cAMP-dependent phosphorylation of the protein PMID: 16093379
24. Neither haloperidol nor the dopamine-D1 receptor antagonist affected synapsin I protein expression. PMID: 16413126
25. These results suggest, therefore, that Ca2+ entrance mediated by P2X7 receptor induces glutamate release and in parallel synapsin-I phosphorylation. PMID: 18242779
26. Synapsin1a modulation by piccolo regulates synaptic vesicle exocytosis PMID: 18519737
27. Data suggest that diabetes has a profound impact on synapsin I and other presynaptic protein expression in the retina, and may provide a mechanism for the well-established defects in vision and the electrophysiological response of the retina in diabetes. PMID: 18662330
28. Synapsin I is embedded in open chromatin in R28 retinal precursor cells. PMID: 18692536
29. Data show that long-term amygdala kindling increases synapsin I immunoreactivity bilaterally in most hippocampal subfields, but not in the caudate nucleus, sensorimotor cortices, or piriform cortex in rats. PMID: 18703092
30. pentachlorophenol exposure during development causes thyroid function vulnerability, testicular hypertrophy in adults, and aberrations of brain gene expression of syn1 PMID: 19082768
31. mW/cm(2) (SAR 14.1 W/kg) microwave radiation can result in the perturbation of the synaptic vesicles associated proteins: synapsin I, synaptophysin, VAMP-2, and syntaxin PMID: 19603498

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KEGG: rno:24949

STRING: 10116.ENSRNOP00000014250

UniGene: Rn.9923