Recombinant Rat Transcription factor A, mitochondrial (Tfam)

1. these results indicate that defect mitochondrial biogenesis in RVLM neurons entailing redox-sensitive and IL-1beta-dependent suppression of TFAM because of the increase in the formation of Keap1/Nrf2 complex, reductions in nuclear translocation of the activated Nrf2 and its binding to the Tfam gene promoter may underlie hypertension developed under the LPS-induced systemic inflammation PMID: 27223823
2. Following skeletal muscle denervation, import of Tfam into the mitochondrion is the critical point of regulation for this protein. PMID: 26063705
3. The modulation of TFAM expression, TFAM-binding to mtDNA and mtDNA content with aging and CR showed a trend shared by the skeletal muscle and liver, but not by the frontal cortex counterpart. PMID: 24631828
4. An age-related decrease in mitochondrial DNA (mtDNA) content and mitochondrial transcription factor A (TFAM) amount, fully prevented by calorie restriction. PMID: 24058615
5. subnormal membrane transport to systems in diabetes impair the transfer of TFAM into the mitochondria, and decreased TFAM-mtDNA binding that results in subnormal mitochondria transcription. PMID: 23255365
6. TFAM can act as a damage-associated molecular pattern and may contribute to the initiation of inflammatory responses in hemorrhagic shock. PMID: 22469910
7. investigation of role of expression of mitochondrial transcription factor A in a model for development of presbycusis (age-related hearing loss) PMID: 21575134
8. Downregulation of Tfam and mtDNA copy number during mammalian spermatogenesis PMID: 11668394
9. reduced binding activity of mtTFA to the D-loop region in the hearts of diabetic rats may contribute to decreased mitochondrial protein synthesis PMID: 11882497
10. results describe the post-translational modifications of mitochondrial transcription factor A (TFAM) in 6- and 28-month-old rat liver PMID: 12535660
11. Results indicate that an impairment of mitochondrial transcription factor A binding to the promoter sequence has a key role in abnormal mitochondrial gene expression, which might explain the mitochondrial dysfunction found in diabetic heart. PMID: 15126286
12. Expression of mtTFA is upregulated in intimal vascular smooth muscle cells of injured rat carotid artery, and suppression of mtTFA expression by antisense oligodeoxynucleotides can attenuate intimal thickening after balloon injury. PMID: 15585199
13. novel redox regulation of NRF-1 phosphorylation and nuclear translocation by phosphatidylinositol 3,4,5-triphosphate kinase/Akt signaling in controlling Tfam induction by an anti-oxidant pro-survival network PMID: 16230352
14. in a physiological condition such as embryonic development the TFAM levels change in order to regulate the transcriptional activity of mtDNA PMID: 16543724
15. protein abundant in liver cells that recognizes DNA adducts induced by the chemical carcinogen N-acetoxy-acetylaminofluorene is identified as TFAM. Its high affinity for DNA damaged by AAAFonfirmed. PMID: 17143337
16. TFAM overexpression protected cell function against the damage induced by high glucose in cardiomyocytes PMID: 19060297
17. The genetic control by the beta cell-specific factor Insulin promoter factor 1 of the ubiquitous gene mitochondrial factor A maintains beta cell mitochondrial DNA vital for ATP production and normal glucose-stimulated insulin secretion. PMID: 19656489

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KEGG: rno:83474

STRING: 10116.ENSRNOP00000000753

UniGene: Rn.18266