Recombinant Rat Transient receptor potential cation channel subfamily V member 4 (Trpv4), partial

1. HO-2 and TRPV4 were also confirmed to form a complex in SFO neurons. PMID: 27436489
2. TRPV4 channels play an important role in the regulation of the adrenergic vascular tone of pulmonary artery smooth muscle cells, but TRPV4 activation mechanism(s) and signaling pathways remain unclear. PMID: 29537229
3. This study was undertaken to investigate the mechanism underlying TRPV4-mediated myocardial ischemia/reperfusion injury. PMID: 28542130
4. In conclusion, TRPV4 differently regulates insulin mRNA expression in INS-1E cells via ERK1/2 and NO-dependent mechanisms. PMID: 28359774
5. These data indicate that TRPV4 is functionally expressed in vestibular ganglion (VG) neurons as an ion channel and that TRPV4 likely participates in VG neurons for vestibular neurotransmission as an osmoreceptor and/or mechanoreceptor. PMID: 27705979
6. irisin may induce endothelium-dependent vasodilation by activating Ca(2+) influx into endothelial cells via TRPV4 channels PMID: 29097199
7. findings demonstrate that FHH rat cerebral arterial myocytes express mRNA transcript and translated protein for TRPV4 channel and display TRPV4-like single-channel cationic current activity that was stretch-sensitive and activation of which increased the open state probability of KCa single-channel current in these arterial myocytes PMID: 28472069
8. Results indicate that osmosensitive transient receptor potential channel 4 protein (TRPV4) controls hypotonic-induced responses in synoviocytes. PMID: 28274876
9. TRPV4 is expressed in mouse and rat gastric epithelium and contributes to ATP release and gastric emptying. PMID: 27350729
10. these results support the link between TRPV4 and p38 and their intermediary role for neuropathic pain in rats with chronic compression of the dorsal root ganglion. PMID: 27366753
11. Data suggested that the impairment of TRPV4-mediated Ca2+ signaling in epithelial cells contributed to the age-related decrease of flow-induced vessel dilation in mesenteric arteries. PMID: 26947561
12. TRPV4 channel activity modulates uterine contractility and might represent a therapeutic target to address preterm labor. PMID: 26702092
13. Overexpression and altered cellular distribution of TRPV4 observed in focal cortical dysplasia suggest that TRPV4 may potentially contribute to the epileptogenesis of focal cortical dysplasia PMID: 26842013
14. Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol PMID: 26294342
15. Aquaporin-mediated fast swelling kinetics play a key role in cell volume regulation (together with TRPV4) and calcium signaling in astrocytes PMID: 26413835
16. hyperglycaemia and diabetes reduce the molecular and functional expression of TRPV4 channels in retinal microvascular endothelial cells. PMID: 26047504
17. We conclude that flow-induced increases in Cai are mediated primarily by TRPV4 in the rat mTAL. PMID: 25980432
18. TRPV4 and calcium-activated potassium channels functionally couple as osmosensors in the paraventricular nucleus PMID: 25421636
19. TRPV4 could inhibit hepatic stellate cells apoptosis partially by regulating autophagy-dependent AKT signaling pathway activation. PMID: 25600591
20. TRPV1/4 channels are potent therapeutic targets for site-specific vasodilation in the kidney PMID: 25069877
21. Data suggest that age-related increases in transient receptor potential vanilloid type 4 (TRPV4) expression in the brain and spinal cord may provide information for investigating the pathogenesis of age-related neurodegenerative diseases. PMID: 24917364
22. We examined the role of TRPV4 channels in the development of high-amplitude spontaneous Ca(2) oscillations in astrocyte endfeet and the inversion of neurovascular coupling after subarachnoid hemorrhage. PMID: 25366609
23. activation of TRPV4 channels mediates flow-induced NO production in thick ascending limb PMID: 24966090
24. TRPV4, TRPC1, and TRPP2 contribute to the ion permeation pore of the channels PMID: 25114176
25. This study provided the first evidence for TRPC1 and TRPV4 channels as potential contributors to mechanosensation in the atrial volume receptors. PMID: 24631674
26. Demonstrate increased TRPV4 expression in the urothelium following stress and that TRPV4 blockade ameliorates stress-induced bladder dysfunction. PMID: 24965792
27. Results show that TRPV4 activation in the intestinal epithelium caused epithelial hyperpermeability in response to NSAID-induced arachidonic acid metabolites and contributed to NSAID-induced intestinal damage. PMID: 24789205
28. ASMC proliferation in response to TRPV4 activity. PMID: 24392954
29. The results of the present study suggest that endothelial TRPV4 channels are present in the endothelium of the rat pulmonary artery and their activation causes endothelium-dependent relaxation involving NO and EDHF. PMID: 24075884
30. our results provide the first evidence that glial cell-expressed TRPV4 is a potential key factor responsible for infrasound-induced neuronal impairment PMID: 24002225
31. These data show, therefore, a particular role of IL-17 in mechanical hyperalgesia, and they suggest that this effect is linked to an activation and upregulation of TRPV4. PMID: 23147107
32. TRPV4 mediates Ca(2+) influx and substance P release in dorsal root ganglion. PMID: 22762361
33. The mechanosensitive ion channel, TRPV4, regulates cardiac fibroblast differentiation to myofibroblasts by integrating signals from TGF-beta1 and mechanical factors. PMID: 23142541
34. the functional status of TRPV4, which underlies mechanosensitive Ca(2 ) signaling in collecting duct cells, inversely correlates with renal cystogenesis in autosomal recessive polycystic kidney disease. PMID: 23411787
35. Coimmunoprecipitation experiments of transfected cells revealed that rat TRPV4 and tubulin beta 5 associated together in a complex. PMID: 22309793
36. TRPV4 protein was predominantly located in the nucleus of cultured neonatal myocytes PMID: 23027348
37. Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling PMID: 23288842
38. Trpv4 expression in female Wistar rats varied with postnatal age, tissue (urothelium, detrusor, or whole bladder), and duration (4-h, 48-h, or chronic) of cyclophosphamide-induced cystitis. PMID: 22865090
39. show that TRPV4 channels are involved in ischemia-induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult PMID: 22761937
40. Relevance of the TRPV4-RyR2 signaling pathway under hypoxic conditions that may lead to pulmonary hypertension. PMID: 22962011
41. TRPV1 is implicated in rat pulmonary arterial smooth muscle cells migration. PMID: 22820913
42. It was shown that both retinal and vestibular ganglion cells can be stimulated reproducibly by lasers and that neuronal responses are driven through transient receptor potential vanilloid 4 channels. PMID: 22442563
43. In this rat model of inflammation, TRPV-4 is expressed and functional in trigeminal ganglion neurons and synovial cells PMID: 22184014
44. TRPV4 was the only member of the TRPV and TRPM subfamilies upregulated in PAs of chronic hypoxic rats. PMID: 22207590
45. Activation of TRPV4 in the bladder, probably urothelium, facilitates the micturition reflex by activation of the mechanosensitive, Cap-insensitive C-fibers of the primary bladder afferents in rats. PMID: 22038643
46. aberrant TRPV4 activity may lead to some types of pathology of sensory and motor nerves PMID: 22187434
47. activation of TRPV4 within the meninges produces afferent nociceptive signaling from the head that may contribute to migraine headache. PMID: 22049072
48. our data suggested that NF-kappaB could be involved in TRPV4-NO pathway in CCD-induced thermal hyperalgesia. PMID: 21356247
49. Pharmacological Trpv4 activation enhanced cerebral arteriogenesis, pinpointing Trpv4 as a possible candidate for the development of new therapeutic concepts. PMID: 21316269
50. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. PMID: 20956320

Show More

Hide All

KEGG: rno:66026

STRING: 10116.ENSRNOP00000001586

UniGene: Rn.64508