Recombinant Rat Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Cacna1a), partial

1. Conclude that expression of the Cacna1a mRNA increased before the onset of alcohol withdrawal syndrome susceptibility, suggesting that altered CaV2.1 channel expression may play a role in AWS pathogenesis. PMID: 29277284
2. postulate that the N-terminus of the truncated channel plays an essential part in its interaction with the full-length CaV2.1, which prevents the correct folding of the wild-type channel PMID: 27260834
3. Thus, GHSR1a differentially inhibits CaV2 channels by Gi/o or Gq protein pathways depending on its mode of activation. PMID: 26283199
4. the consensus motifs of S-nitrosylation were much more abundant in Cav2.2 than in Cav1.2 and Cav2.1. PMID: 26507659
5. data suggest that the different roles that Ca(V)2.1 and Ca(V)2.2 play in MNC secretion may be a result of the different levels of expression of Ca(V)2.1 in VP and OT MNCs PMID: 24344901
6. the contribution of Ca(V)2.1 to complex cognitive functions PMID: 24205277
7. By transducing presynaptic action potential firings into unique Ca(2+) signals and vesicle release profiles, Cav2.1 channels contribute to the encoding and processing of neural information PMID: 24453334
8. Calcium currents are enhanced by alpha2delta-1 lacking its membrane anchor PMID: 22869375
9. Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2+) channels. PMID: 22589533
10. Lowering glucose level enhances the activity of P/Q type Ca(2+)channels and elevates [Ca(2+)](i) level in hypothalamic arcuate nucleus neurons via inhibition of GSK3beta. PMID: 22504905
11. Cav2.1 channels, along with dopamine D3 receptors, mediate upregulation of dopamine D2 receptors in dopamine-denervated striatum. PMID: 21389298
12. The invertebrate LCav2 channel does not exhibit any of the hallmarks of mammalian voltage-dependent G-protein inhibition. PMID: 20511524
13. Neurons in the inferior colliculus express Ca(2+) channel alpha(1A), alpha(1B), alpha(1C), alpha(1D), and alpha(1E) subunits. PMID: 12895521
14. Regulation of Cav2.1 channel in response to local Ca2+ increases calmodulin binding and negative regulation during more global Ca2+ increases calcium inactivation. PMID: 14673106
15. Cacna1a subunit is apparently associated with the glutamatergic synapses and may play a role in the regulation of excitatory neurotransmission and contribute to the generation of postsynaptic calcium transport. PMID: 15090043
16. The PP2calpha-Ca2+ channel complex is responsible for rapid dephosphorylation of Ca2+ channels and may contribute to regulation of synaptic transmission in neurons. PMID: 15728831
17. Differential regulation of CaV2.1 channels by CaM, VILIP-2, CaBP1, and other neurospecific Ca2+-binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission. PMID: 16049183
18. nonmyristoylated CaBP1 and VILIP-2 bind to CaV2.1 channels and regulate them like CaM, whereas myristoylation allows differential, Ca2+-independent regulation by the inactive EF-hands of CaBP1 and VILIP-2 PMID: 16049184
19. These results expand the known diversity of CaV2.1 transcripts in cerebellar Purkinje cells, and propose the selective expression of distinct assortments of CaV2.1 transcripts in different brain neurons and species. PMID: 16278278
20. Ca2+-dependent inactivation of Ca(v)2.1 depends on a subplasmalemmal Ca2+ microdomain that is affected by the amplitude of the Ca2+ current and differentially modulated by distinct Ca2+ buffers PMID: 16373336
21. Data show that the Drosophila cacophony ts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation PMID: 16820014
22. brain BKCa channels are assembled into complexes with calcium channels Cav1.2, Cav2.1 & Cav2.2; complex formation with Cav channels enables BKCa-mediated membrane hyperpolarization controlling neuronal firing & release of hormones & transmitters PMID: 17068255
23. Thus, the GRY rat with P/Q-type Ca(2+) channel disorders is a useful model for studying absence epilepsy and Cacna1a-related diseases. PMID: 17196942
24. Essential in Ca++ selectivity over other divalent cations, at a conserved EEEE locus. PMID: 17893194
25. Novel splice variants of rat CaV2.1 that lack much of the synaptic protein interaction site are expressed in neuroendocrine cells. PMID: 18390553
26. Introduction into Ca(v)2.1 of the homologous mutation of Ca(v)1.2 causing the Timothy syndrome questions the role of V421 in the phenotypic definition of P-type Ca(2+) channel. PMID: 18536931

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KEGG: rno:25398

STRING: 10116.ENSRNOP00000059641

UniGene: Rn.87769