Recombinant Saccharomyces cerevisiae DNA repair protein RAD9 (RAD9), partial

1. The initial telomere-proximal unstable chromosome is increased in mutants in telomerase subunits, Tel1, and even Rad9, with no known telomere-specific function. Defects in Tel1 and in Rrm3, a checkpoint protein kinase with a role in telomere maintenance and a DNA helicase, respectively, synergize dramatically to generate unstable chromosomes, further illustrating the consequence of replication error in the telomere. PMID: 27716774
2. The checkpoint protein Rad9 limits the action of Sgs1/Dna2 in double-strand break resection by inhibiting Sgs1 binding/persistence at the double-strand break ends. PMID: 25637499
3. in cells lacking Sae2, Rad9/53BP1 contributes to keep Mre11 bound to a persistent DSB, protecting it from extensive DNA end resection, which may lead to potentially deleterious DNA deletions and genome rearrangements. PMID: 25569305
4. The findings suggest that Rad9 functions together with Aft1 on DNA damage-prone chromatin to facilitate genome surveillance, thereby ensuring rapid and effective response to possible DNA damage events. PMID: 25300486
5. We suggest a novel model for Chk1 activation where Cdc28 regulates the constitutive interaction of Rad9 and Chk1. The Rad9/Chk1 complex is then recruited at sites of DNA damage where activation of Chk1 requires additional DDR-specific protein kinases. PMID: 23593009
6. Multiple phosphorylation of Rad9 by the cyclin-dependent kinase is required for DNA damage checkpoint activation. PMID: 23070520
7. Slx4-Rtt107 complex modulates Rad53 activation by a competition-based mechanism that balances the engagement of Rad9 at replication-induced lesions PMID: 23160493
8. show that recombination intermediates take longer to form in cells lacking Rad9 PMID: 22484486
9. a ternary complex of Dpb11, Mec1 and another key mediator protein Rad9 is required for efficient Rad9 phosphorylation by Mec1 in vitro, and for checkpoint activation in vivo. PMID: 21946560
10. Rad9 chromatin binding is cell cycle-regulated by CDK1 activity. PMID: 20700441
11. a novel role for members of the S-phase DNA damage checkpoint, RAD9, RAD17 and RAD24 in suppressing mutagenic post-replicative repair was described. PMID: 20472512
12. report that Rad9 binds to sub-telomeric chromatin, upon telomere uncapping, up to 10 kb from the telomere. PMID: 19880356
13. Rad9 acts as a bona fide signaling adaptor that enables Rad53 phosphorylation by Mec1. PMID: 16085488
14. Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9 PMID: 16166626
15. Rad9 has a role in promoting efficient repair of DNA DSBs by homologous recombination PMID: 16650810
16. These findings indicate that constitutive Tudor domain-mediated and damage-specific BRCT domain-phospho-H2A-dependent interactions of Rad9 with chromatin cooperate to establish G1 checkpoint arrest. PMID: 17721446
17. The tandem tudor region of Rad9 directly interacts with single-stranded DNA and double-stranded DNAs of various lengths and sequences. PMID: 17726056
18. Binding of the checkpoint protein Rad9, through its Tudor domain, to methylated histone H3-K79 inhibits resection at DSBs and uncapped telomeres. PMID: 18418382
19. Interaction between checkpoint genes RAD9, RAD17, RAD24, and RAD53 involved in the determination of yeast Saccharomyces cerevisiae sensitivity to ionizing radiation PMID: 18727386
20. checkpoint genes RAD9, RAD17, RAD24, and RAD53 belong to a single epistatic group designated RAD9 and govern the same pathway. Genes RAD9 and RAD53 have a positive effect on sensitivity to gamma-radiation, whereas RAD17 and RAD24 have a negative effect PMID: 18825953
21. the role of the histone H3K79 methyltransferase Dot1, Rad9 checkpoint adaptor in the cohesin-dependent repair by sister chromatid recombination of replication-dependent HO-induced double-strand break PMID: 19332880
22. RAD9-dependent gene up-regulation is required for nucleotide excision repair only when this process is coupled to transcription. PMID: 19428371

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KEGG: sce:YDR217C

STRING: 4932.YDR217C