Recombinant Saccharomyces cerevisiae Mitogen-activated protein kinase SLT2/MPK1 (SLT2)

1. MPK1/SLT2 links multiple stress responses with gene expression in S.cerevisiae by phosphorylating Tyr1 of the RNAP II C terminal domain. PMID: 29220656
2. Mpk1 molecules carrying a mutation in Tyr-268 executed the entire downstream biological function, using mechanisms that do not require activation of catalysis or the catalytic Lys-54 residue.It should be emphasized that although Mpk1(Y268C/A+K54R) and Mpk1(Y268C/A+T190A+Y192F) molecules are biologically active, they rescue mpk1 and mkk1mkk2 cells less efficiently than Mpk1(Y268C/A). PMID: 27413009
3. cooperation between SAGA and SWI/SNF complexes is required for efficient transcriptional responses regulated by the yeast MAPK Slt2 PMID: 27112564
4. Slt2 phosphorylates the MAPK phosphatase Msg5 both in the N-terminal regulatory and C-terminal catalytic domains. PMID: 26786099
5. Mpk1 and the greatwall kinase pathway serve TORC1 to coordinate the phosphorylation status of Sic1 and consequently G1-S cell cycle progression with nutrient availability. PMID: 26356805
6. Authors show that in sod1, grx5, and grx3 grx4 slt2 mutants, all of which are affected by chronic oxidative stress, the overexpression of Slt2 favors vacuole fusion through a mechanism dependent on an active actin cytoskeleton. PMID: 23956390
7. Our results point to a common mechanism for the regulation of ER inheritance in which Slt2p activity at the bud tip controls the association of the ER with the actin-based cytoskeleton. PMID: 23924898
8. Slt2p is activated by different inputs in response to nutrient signals and mediates growth control through TORC1 (target of rapamycin 1 complex)-Sch9p (suppressor of cdc25) and PKA (protein kinase A) at low temperatures PMID: 22747505
9. Slt2 is required for the induction of several genes in response to arsenate exposure. PMID: 20737431
10. The authors suggest that the observed length variability may influence biological features of the Slt2 protein, allowing it to adapt swiftly in order to survive in unusual environments. PMID: 20586115
11. mechanism by which the MAP kinase Slt2 and Mlp1 control mRNA export factors during heat shock stress PMID: 20823268
12. A new role for the Slt2p MAP kinase cascade protects cells from programmed cell death through cyclin C destruction. PMID: 16387872
13. Cell integrity MAPK (mitogen-activated protein kinase) function can be provided in yeast cells by either the native Slt2(Mpk1)p of yeast or by a heterologously expressed human ERK5. PMID: 17052197
14. In this study, we demonstrate that transcriptional activation of a Gal4-Slt2p fusion is responsive to cell wall stress and requires phosphorylation of Slt2p. PMID: 17397108
15. Retrophosphorylation of MKK1 and MKK2 MAPKKs by the SLT2 MAPK in the yeast cell integrity pathway is reported. PMID: 17711850
16. The Hos2p complex is required for proper activation of the Mpk1p/Slt2p cell integrity kinase cascade. PMID: 18487345
17. Data show that phosphorylation of Ser423 specifically blocked SBF activation by preventing Mpk1 association with Swi4, revealing a novel mechanism for regulating MAPK target specificity. PMID: 19805511

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KEGG: sce:YHR030C

STRING: 4932.YHR030C