Recombinant Vesicular stomatitis Indiana virus Matrix protein (M)

1. VEGF-D-enhanced metastasis was evidently reversed by MP. MP significantly reduced the invasion of VEGFD-SK cells, tumor volume, lymphatic metastasis rates and lymphatic vessel density compared with control groups PMID: 27211072
2. vesicular stomatitis virus M protein interacted efficiently with Rae1-Nup98 complexes associated with the chromatin fraction of host nuclei, consistent with an effect on host transcription PMID: 23028327
3. These findings indicate that the PSAP motif plays a direct role in regulating cytopathogenicity in a species-dependent manner, and suggest that the intact PSAP motif may be important for maintaining virus persistence in an insect host. PMID: 23170175
4. study re-examined the contribution of the PSAP motif to VSV budding; VSV M binds TSG101 [tumour susceptibility gene 101] through its PSAP motif; double mutant with point mutations in both PSAP and PPPY motifs is impaired compared with a single mutant in the PPPY motif, indicating the PSAP motif partially compensates for lack of the PPPY motif PMID: 22190013
5. VSV M protein inactivates the cellular Akt signaling pathway. PMID: 20980511
6. These findings indicate that the host shut-off activity of the M protein dominates vesicular stomatitis virus cytotoxicty, whilst the fusion-active G protein is mainly responsible for the cytotoxicity remaining with M-mutant vesicular stomatitis virus. PMID: 20631091
7. hyperphosphorylation of VSV M protein was observed in both cell lysates and viral particles from IFN-beta-treated neuronal cells. Hyperphosphorylated VSV M protein was found to inhibit its association with VSV nucleocapsid PMID: 19951173
8. VSV expressing the mutant M protein induces apoptosis via the death receptor apoptotic pathway, a mechanism distinct from that induced by VSV expressing the wt M protein. PMID: 15767418
9. first evidence that M protein alone is able to impose the correct budding curvature on the membrane PMID: 16298982
10. Glycoprotein (G protein) and M protein microdomains were not colocalized in the plasma membrane outside the virus budding sites PMID: 18367537
11. M protein mutants of VSV are less virulent than wild type and can induce an antibody response similar to that in mice infected with the wt virus. PMID: 18614644
12. The authors propose that low-pH conformational changes in G protein promote acidification of the virus interior, which facilitates the release of M from ribonucleoprotein particles during uncoating. PMID: 19776119

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KEGG: vg:1489833