Code | CSB-RA845175A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
The recombinant DGCR8 antibody is a monoclonal antibody made in vitro using the DGCR8 antibody genes that are typically expressed from a plasmid in a stable mammalian cell line. The genes coding for the DGCR8 antibody will ultimately assemble into a fully functional antibody after translation. The synthesized antibody is the recombinant antibody against DGCR8. It underwent purification using affinity-chromatography. This recombinant DGCR8 antibody is suitable for use in the ELISA, WB to detect the DGCR8 protein from Human.
DGCR8 is an allele located in the ql1.2 region of human chromosome 22. It is associated with DiGeorge Syndrome (DGCS), so it is named DGCR83. DGCR8 is an RNA-binding protein involved in the synthesis of microRNAs. In the synthesis of microRNAs, it binds pri-microRNAs and promotes the cleavage of Drosha by interacting with Drosha and stabilizing microprocessors, which regulate the production of microRNAs and affect the proliferation, migration, and invasion of tumors4,5. The high expression of DGCR8 promotes the occurrence, development, and metastasis of cancer, including kidney clear cell carcinoma, thyroid carcinoma, and ovarian cancer. DGCR8 is abnormally expressed in TNBC specimens. Besides, the knockdown of DGCR8 inhibited cell migration and invasion in TNBC cells, while the overexpression of DGCR8 promoted cell migration and invasion in TNBC cells. The above results indicated that DGCR8 promotes the metastasis of TNBC and may act as an oncogene.
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