NFIB Recombinant Monoclonal Antibody

1. High NF1B expression is associated with cell growth, aggressiveness, metastasis in gastric cancer. PMID: 30015981
2. Studied role of miR-30d in tumor invasiveness and migration in non-small lung cancer (NSCLC). Found miR-30d suppressed cell migration and invasion by directly targeting nuclear factor I B (NFIB) in NSCLC. PMID: 28861760
3. Study highlighted the paradoxical involvement of NFIB in both the inhibition and promotion of tumor development as well as progression in different malignancies; especially between different tumor subtypes within a single organ system, such as in lung, brain and skin,which corroborates its diverse and distinct roles in specific tissues and cell types. [review] PMID: 28596133
4. we report that the transcription factor NFIB is associated with significantly improved survival in glioblastoma PMID: 27083054
5. High NFIB levels are associated with expansive growth of a poorly differentiated and almost exclusively E-cadherin (CDH1)-negative invasive tumor cell population. PMID: 27373156
6. low expression of NFIB was significantly associated with biologically more aggressive subtypes and, ultimately, poorer survival in lung adenocarcinoma patients PMID: 27357447
7. Data indicate that NFIB protein increases EZH2 protein expression downstream of BRN2 protein, which further decreases MITF protein levels. PMID: 28119061
8. In benign prostatic hyperplasia, luminal NFIB loss correlated with more severe disease. in androgen-dependent LNCaP prostate cancer cells demonstrated that 64.3% of NFIB binding sites are associated with AR and FOXA1 binding sites. PMID: 26677878
9. These data suggest that germline genetic variation at rs7034162 is important in osteosarcoma metastasis and that NFIB is an osteosarcoma metastasis susceptibility gene. PMID: 26084801
10. Further studies also discovered a conserved feedback regulatory circuitry formed by NFIB and miR-365 in cutaneous squamous cell carcinoma development PMID: 24949940
11. multivariate analysis co-overexpression of NFIB, RANK and RANKL significantly increased the risk of metastasis with an odds ratio of 13.59 PMID: 25764026
12. Increased expression of NF1B is associated with pilocytic astrocytoma. PMID: 23161775
13. The data demonstrates that the autism spectrum disorder-associated A-C intronic haplotype of the ENGRAILED2 gene is a transcriptional activator, and both CUX1 and NFIB mediate this activity. PMID: 22180456
14. Tissue microarray results from invasive breast cancer patients, and the immunohistochemistry results showed a significant association between NFIB expression and nuclear grade, estrogen receptor, and HER2 expression status. PMID: 21925980
15. study revealed that miRNA (miRs-372/373) can promote HBV expression through a pathway involving the transcription factor PMID: 21608007
16. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation PMID: 21764851
17. these results suggest that NFIB is a novel and specific biomarker for oxaliplatin resistance in human cancers PMID: 21087353
18. The the MYB-NFIB fusion characterizes a subset of ACCs and contributes to MYB overexpression. PMID: 20702610
19. expression of NFI-B2 impairs CD4 transcription on CDd4-positive primary T-lymphocytes and cell lines in HIV-1 infection PMID: 12639247
20. C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in tumor cells PMID: 17511965
21. the rearrangement of NFIB might be associated with deep-seated lipomas, such as retroperitoneal or gastro-intestinal lipomas PMID: 18663748
22. Knockdown of NFIB and NFIC expression using siRNA decreased and increased IGFBP5 expression, respectively. PMID: 18809517
23. lipomas containing NFIB rearrangements may be related to peculiar clinicohistologic features, including large size, deep situation, infiltration of surrounding muscles, or precocious occurrence. PMID: 19837271

Show More

Hide All

HGNC: 7785

OMIM: 600728

KEGG: hsa:4781

STRING: 9606.ENSP00000370340

UniGene: Hs.644095