Code | CSB-RA632595A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IF | 1:20-1:200 |
FC | 1:20-1:200 |
IP | 1:200-1:1000 |
In the glycolytic pathway, PKM2 as a limiting glycolytic enzyme catalyzes the transfer of a phosphate group from phosphoenolpyruvate to ADP generating pyruvate and ATP, which is important for tumor metabolism and growth. Apart from its pyruvate kinase activity, PKM2 also possesses non-metabolic activities such as acting as a protein kinase to phosphorylate various protein targets. PKM2 also participates in many other processes regarding tumor pathology, including cancer metastasis, epithelial-mesenchymal-transition (EMT), gene expression, mitosis, cellular proliferation, apoptosis, DNA damage response, and exosome secretion.
This recombinant PKM antibody was developed with the Single B cell platform. The main process included identification and isolation of single B cells; amplification and cloning of PKM antibody gene; expression, screening, and identification of antibody specificity. And this PKM antibody has been validated in ELISA, WB, IHC, IF, FC, IP.There are currently no reviews for this product.