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In the glycolytic pathway, PKM2 as a limiting glycolytic enzyme catalyzes the transfer of a phosphate group from phosphoenolpyruvate to ADP generating pyruvate and ATP, which is important for tumor metabolism and growth. Apart from its pyruvate kinase activity, PKM2 also possesses non-metabolic activities such as acting as a protein kinase to phosphorylate various protein targets. PKM2 also participates in many other processes regarding tumor pathology, including cancer metastasis, epithelial-mesenchymal-transition (EMT), gene expression, mitosis, cellular proliferation, apoptosis, DNA damage response, and exosome secretion.This recombinant PKM antibody was developed with the Single B cell platform. The main process included identification and isolation of single B cells; amplification and cloning of PKM antibody gene; expression, screening, and identification of antibody specificity. And this PKM antibody has been validated in ELISA, WB, IHC, IF, FC, IP.
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