Code | CSB-RA613684A13phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
CUSABIO designed the vector clones for the expression of a recombinant CDC37 antibody in mammalian cells. The vector clones were obtained by inserting the CDC37 antibody heavy and light chains into the plasma vectors. The recombinant CDC37 antibody was purified from the culture medium through affinity-chromatography. It can be used to detect CDC37 protein from Human in the ELISA, WB.
The phospho-CDC37 (S13) antibody is specific for phosphorylated CDC37. CDC37 function is modulated through phosphorylation at S13 by protein kinase CK2. Phosphorylation of CDC37 at S13 is essential for its kinase binding activity and its ability to stimulate the nucleotide-regulated conformational switching of Hsp90. CDC37 suppressed the ATP hydrolysis step and allows the prolonged combination of Hsp90 dimers with client proteins and more effective chaperone activity.
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