Code | CSB-RA015261A11phHU |
Size | US$210 |
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Application | Recommended Dilution |
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IF | 1:20-1:200 |
The phospho-MYB (S11) recombinant monoclonal antibody is a highly specific antibody against the phosphorylated human MYB at Ser 11. This phospho-MYB (S11) antibody was expressed by transfecting the human phospho-MYB (S11) monoclonal antibody gene-vector clones into the cell line for in vitro production and subsequent purification from the tissue culture supernatant (TCS) through affinity-chromatography. Its isotype matches with the rabbit IgG. This phospho-MYB (S11) antibody can be used in ELISA and IF applications.
Phosphorylation of c-Myb has been linked to the modulation of c-Myb/DNA binding. Ramsay et al. found that constitutive phosphorylation by CK2 at serines 11 and 12 is required for full-length c-Myb to have high-affinity specific DNA binding activity in vitro. CK2 phosphorylation of c-Myb at serines 11 and 12 lowers the effectiveness of c-Myb DNA binding to low-affinity sites, according to Luscher et al.
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