Code | CSB-RA022948A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
IHC | 1:50-1:200 |
IP | 1:200-1:1000 |
The recombinant SUMO1 antibody production commenced with the obtaining of genes encoding antibody against SUMO1. Antibody genes were obtained by sequencing and screening DNA reversely transcribed from RNA that was extracted from the B cells isolated from immunized animals. These genes were cloned into plasma vectors and subsequently transfected into a mammalian cell line for production. The product is the recombinant SUMO1 antibody. It underwent purification using affinity-chromatography from the cell culture medium. This recombinant SUMO1 antibody has been validated to detect the SUMO1 protein from Human in the ELISA, IHC, FC, IP.
SUMO1 is a small ubiquitin-related modifier protein covalently conjugated to many cellular and viral protein targets by an isopeptide bond via the C-terminus. It takes part in the modulation of some kinases such as cyclin-dependent kinase 6 and several transcription factors. SUMO1 is involved in various cellular activities, including nuclear transport, transcriptional modulation, apoptosis, and protein stability. Because SUMO1 aids to maintain calcium homeostasis in the mitochondria of heart cells, it is a key component in cardiac function. SUMO1-SERCA2A interaction plays a critical role in the regulation of calcium levels inside cardiac myocytes.
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