Code | CSB-RA997969A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
TINF2 is the encoding gene for TIN2, which acts as an adaptor crucial for the recruitment, formation, and stabilization of the shelterin complex. It mediates the localization of three key DNA interacting proteins (TRF1, TRF2, and POT1) at telomeres. It is essential for shelterin assembly at the telomere and is an important regulator of telomere length. Mutations in TINF2 cause short-telomere syndromes. Deletion of TIN2 is embryonically lethal, and conditional knockout of TIN2 in mouse embryo fibroblasts (MEFs) leads to growth arrest. Upregulation of TIN2 has been commonly observed in many human malignancies.
The recombinant TINF2 antibody production commenced with the obtaining of genes encoding antibody against TINF2. Antibody genes were obtained by sequencing and screening DNA reversely transcribed from RNA that was extracted from the B cells isolated from immunized animals. These genes were cloned into plasma vectors and subsequently transfected into a mammalian cell line for production. The product is the recombinant TINF2 antibody. It underwent purification using Affinity-chromatography from the cell culture medium. This recombinant TINF2 antibody has been validated to detect the TINF2 protein from Human, Mouse, Rat in the ELISA, WB.There are currently no reviews for this product.