TMOD2 Recombinant Monoclonal Antibody

Tropomodulin-2, also known as neuronal tropomodulin, plays a critical role in regulating actin filament dynamics by capping the pointed ends of actin filaments in neurons. This function is essential for maintaining neuronal architecture, synaptic plasticity, and proper nervous system development. Researchers investigating neurodegenerative diseases, neuronal cytoskeletal organization, and brain development will find TMOD2 a compelling target for understanding how actin dynamics influence neuronal function and pathology.

This recombinant monoclonal antibody, generated from clone 10B12, offers the reproducibility and consistency that demanding research protocols require. Because the antibody sequence is defined and production occurs in controlled recombinant systems, you can expect reliable performance across experiments and over time, eliminating the lot-to-lot variability that can complicate long-term studies or multi-site collaborations.

Validation studies demonstrate this antibody's versatility across multiple experimental platforms. Immunohistochemistry performed on paraffin-embedded human tissues reveals clear staining in both brain tissue, where TMOD2 is abundantly expressed, and melanoma samples, suggesting potential utility in cancer research contexts. Flow cytometry analysis using the SH-SY5Y neuroblastoma cell line, a widely used model for neuronal studies, shows distinct positive signal separation from isotype controls, confirming specific intracellular detection following fixation and permeabilization.

The antibody is supplied in a glycerol-containing buffer optimized for long-term stability at freezer temperatures, and affinity purification ensures high purity for sensitive downstream applications. Whether you are mapping TMOD2 expression patterns in clinical specimens, characterizing neuronal differentiation in cell culture models, or exploring its involvement in disease states, this antibody provides a dependable tool for advancing your research into actin-based neuronal biology.