Rabbit anti-Mouse IgG Fc Antibody;HRP conjugated

Datasheet

Code CSB-PA00580F0Rb
Product Type Secondary Antibody
Size US$169Purchase it in Cusabio online store
(only available for customers from the US)
Abbreviation Mouse IgG Fc fragment
Immunogen Mouse IgG Fc fragment
Raised in Rabbit
Species Reactivity Mouse
Tested Applications ELISA
Relevance The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. InIgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody’s two heavy chains; IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2–4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and α-2,6 linked sialic acid residues. The other part of an antibody, called the Fab region, contains variable sections that define the specific target that the antibody can bind. By contrast, the Fc region of all antibodies in a class are the same for each species; they are constant rather than variable. The Fc region is, therefore, sometimes incorrectly termed the "fragment constant region".
Form Liquid
Conjugate HRP conjugated
Storage Buffer Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method Caprylic Acid Ammonium Sulfate Precipitation purified
Isotype IgG
Clonality Polyclonal
Protocols ELISA Protocol
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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