Recombinant D-glucuronyl C5-epimerase(hse-5)

Code CSB-CF009492CXY
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P46555
Storage Buffer Tris-based buffer,50% glycerol
Species Caenorhabditis elegans
Sequence MKCLRWRSNRHRIYLLVACGALFLLNRHLTQEESRIDEEDEELTQVDVNEDDKKIECEPPGSIESKCIADNGKSMKCWKDEEDVYFPVSYLKKRFDMTGKLGKDGSTFELYTSYAKMRSPDSTYDPLGPFGHFSTYSVETRDRVRCVSAKTDVPMSTQWDPIPYYYPIQISQYGLQHYSRMKLDSISNKSEASPKDDVILGVNSKEWKGAAGMHETTERLFFNDEQMGKVVNISAGAALANAGAYVYLDKSPDLHVISFDWKPYEANSSFTVLAKMKQDDLLVLINYVYSEGNGKCVWQEEERISDDYIVQKPKKDGQVSYSYSYIGNSPIGEWSTVTRDLLVDVARALSSGDNRKKDDNVVLHAGDLRLVSLGFRGELTVKQKITQRREQHSHAFYAAADWLVKNQNDRGGWSVPVERSIAERKLVLPPGWHSAMAQGHGISVLTRAFKHFNDEKYLKSAAKALKLFKINSSDGGVRGEFFGNIWYEEYPTTPGSFVLNGFLYSLIGLYDLSQLELMIDENDETMRAKIQEAQELYSAGVRSLKQLLPLYDTGSGTIYDLRHVALGTAPNLARWDYHAVHVYLLKWIAGIEKDEVLSKTADRWIGYAYGKRAKHN
Source in vitro E.coli expression system
Gene Names hse-5
Protein Names Recommended name: D-glucuronyl C5-epimerase EC= 5.1.3.- Alternative name(s): Heparin/heparan sulfate:glucuronic acid C5-epimerase
Expression Region 1-616
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acids (By similarity). Plays a role in the early migration of AQR and PQR neurons, which descend from the Q neuroblasts
Subcellular Location Cell membrane, Single-pass type II membrane protein, Secreted, extracellular space, extracellular matrix, basement membrane
Protein Families D-glucuronyl C5-epimerase family
Tissue Specificity Expression in comma stage embryos is strong in the hypodermis and intestine and weaker in the head region. In late embryos, larval, and adult stages, expressed primarily in hypodermis and intestine.
Database Links

KEGG: cel:CELE_B0285.5

STRING: 6239.B0285.5.2

UniGene: Cel.10958

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