Recombinant Danio rerio Sphingosine 1-phosphate receptor 2(s1pr2)

Code CSB-CF884843DIL
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q9I8K8
Storage Buffer Tris-based buffer,50% glycerol
Species Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence MTTCRLFAGFCQAVTMSKYSQYFNKTLIQVHYLTAKEMTAEELRDRIESKQSLSSLNILF VVICSIIILENLLVLIAVFRNKKFHSAMFFFIGNLAFSDLLAGSAYIANIFLSGPRTFHL TPVQWFIREGTAFIALSASVFSLLAIAIERYIAITKVKVYGSNKTCRMFLLIGACWVMSI LLGGLPIIGWNCINNLDDCSAVLPLNTRYYIRFVVTIFSIILLSIVILYVRIYLIVRTSH QEATNSPAYALLKTVTIVLGVFIICWLPAFTILLLDTSCKMKQCPILNNAGIFFSFATLN SALNPLIYTLRSKDMRKEFLRVLCCWGLLNCGRPPHRCMVPLKSSSSMEHCTNKHEHQSI PIMQDCTTCV
Source in vitro E.coli expression system
Gene Names s1pr2
Protein Names Recommended name: Sphingosine 1-phosphate receptor 2 Short name= S1P receptor 2 Short name= S1P2 Alternative name(s): Sphingosine 1-phosphate receptor Edg-5 Short name= S1P receptor Edg-5
Expression Region 1-370
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithlial integrity during vertebrate embryogenesis.
Involvement in disease Defects in s1pr2 are a cause of heart development abnormality named miles apart (mil). In all vertebrates, the myocardial progenitors involute early during gastrulation and come to occupy bilateral positions in the anterior lateral plate mesoderm (LPM). During somitogenesis, these cells undergo a second phase of migration toward the midline and fuse to form the definitive heart tube. Defects in S1PR2 disrupt this process, leading to the formation of two laterally positioned hearts (cardia bifida). The mil phenotype for which two recessive alleles exist, mil(m93) and mil(te273) are fully penetrant. Mil(m93)/mil(te273) transheterozygous embryos display the same phenotype as homozygotes for either single mutant allele. In addition to cardia bifida, mil mutants display epithelial tail blisters, indicative of a defect in epithelial integrity.
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Database Links

KEGG: dre:170457

STRING: 7955.ENSDARP00000053105

UniGene: Dr.110802

Pathway Sphingolipid signaling pathway

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