Recombinant Drosophila melanogaster Potassium voltage-gated channel protein Shaker (Sh)

1. S4-S5 linker movement during activation and inactivation in voltage-gated K(+) channels. PMID: 29959207
2. Authors provide evidence that in the Drosophila Shaker voltage-gated K(+) channels the S3 domain acts as an extracellular hydrophobic 'stabilizer' for the S4 domain biasing the gating chemical equilibrium toward the open state. PMID: 23542156
3. This study demonstrates that Shaker is not always a good model for Kv1 channels for ligand binding. PMID: 23398369
4. The xenon requirement in Drosophila melanogaster is not influenced by a single gene mutation at the shaker locus, whereas a reduced expression of a nonselective cation channel leads to an increased xenon requirement. PMID: 22761550
5. Data show several strong Cysteine-Cadmium-Cysteine bridges in Shaker potassium channel. PMID: 22538811
6. Synaptic transmission at the larval neuromuscular junction and the transient Shaker potassium current IA in larval muscles have been characterized. PMID: 20429677
7. interaction of the voltage-dependent Shaker potassium channel with the channel-blocking toxin kappa-conotoxin-PVIIA PMID: 11820396
8. Shaker K+ channels contribute to the information capacity of Drosophila photoreceptors PMID: 12571596
9. Second-order kernels of Shaker potassium channel mutants lack a large, early amplification and demonstrate a novel role for Shaker K+ channels in amplifying and accelerating the voltage response of wild-type photoreceptors. PMID: 12761281
10. Results suggest that the external TEA binding site is not within the membrane electric field and that the voltage dependence of TEA block in K+ solutions arises through a coupling with the movement of K+ ions through part of the membrane electric field. PMID: 12885878
11. reduce the metabolic cost of neural information in Drosophila photoreceptors. PMID: 12952637
12. The Shaker voltage-gated potassium channel pore opens when the inner helix bends at a conserved glycine gating hinge. PMID: 15491131
13. Shaker, which encodes a voltage-dependent potassium channel controlling membrane repolarization and transmitter release, may thus regulate sleep need or efficiency; short-sleeping Shaker flies have a reduced lifespan PMID: 15858564
14. observations highlight crucial control of nerve terminal excitability by Shaker & Shab channels to confer temporal patterns of synaptic transmission & suggest participation of these channels in activity-dependent synaptic plasticity PMID: 16763031
15. ShB(delta)K wes activated by binding with toxin 6-bromo-2-mercaptotryptamine (BrMT). PMID: 16801385
16. These results suggest that cooperative insertion of the voltage-sensor transmembrane helices is a property common to K(v) channels and that the degree of cooperativity depends on a balance between electrostatic and hydrophobic forces. PMID: 17488813
17. synaptic strength and synaptic strength at neuromuscular junctions along the dorsal-ventral differentials at physiological Ca(2+) levels were not significantly altered in slowpoke (slo) and Shaker (Sh) mutants PMID: 18539401
18. allosteric communication across disparate regions of the channel protein and between evolved and regulated amino acid changes introduced by RNA editing. PMID: 19114634

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KEGG: dme:Dmel_CG12348

STRING: 7227.FBpp0088599

UniGene: Dm.7088