Recombinant Drosophila virilis Serine protease HTRA2, mitochondrial(HtrA2)

Code CSB-CF453818DMP
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. B4LY58
Storage Buffer Tris-based buffer,50% glycerol
Species Drosophila virilis (Fruit fly)
Sequence ALASTMVAQREELTPTISARALSGRRREFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQ PITASNGSGFVIEQNGLILTNAHVVINKPNTMVQVRLSDGRTFPATIEDVDQTSDLATLR IQVNNLSVMKLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINY LQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAARRRKGSA YKTGYPVKRYMGITMLTLTPDILFELKSRTQNMPNTLSHGVLVWKVIVGSPAHSGGLQPG DIVTHINKKEIKNSSDVYDALADGKKELDIVILRGVKQMRVTITPEDP
Source in vitro E.coli expression system
Gene Names HtrA2
Protein Names Recommended name: Serine protease HTRA2, mitochondrial EC= 3.4.21.108 Alternative name(s): High temperature requirement protein A2
Expression Region 74-421
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
Subcellular Location Mitochondrion intermembrane space, Single-pass membrane protein, Mitochondrion membrane, Single-pass membrane protein
Protein Families Peptidase S1C family
Database Links

KEGG: dvi:Dvir_GJ24448

STRING: 7244.FBpp0238865

Pathway Apoptosis

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