Recombinant Human Beta-1,3-galactosyltransferase 4(B3GALT4)

Code CSB-CF002492HU
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names B3GALT4
Uniprot No. O96024
Alternative Names 3-galactosyltransferase 4; 3-galactosyltransferase; 3-GalTase 4; b3Gal-T4; B3GALT4; B3GT4_HUMAN; Beta 1,3 galactosyltransferase 4; Beta 1,3 GalTase 4; Beta 3 galactosyltransferase 4; Beta-1; Beta3Gal-T4; Beta3GalT4; Gal T2; GAL-T2; GALT2; GalT4; Ganglioside galactosyltransferase; OTTHUMP00000029128; UDP Gal:betaGlcNAc beta 1,3 galactosyltransferase; polypeptide 4; UDP galactose:beta N acetyl galactosamine beta 1,3 galactosyltransferase; UDP-galactose:beta-N-acetyl-galactosamine-beta-1
Species Homo sapiens (Human)
Expression Region 1-378
Target Protein Sequence MQLRLFRRLLLAALLLVIVWTLFGPSGLGEELLSLSLASLLPAPASPGPPLALPRLLIPNQEACSGPGAPPFLLILVCTAPENLNQRNAIRASWGGLREARGLRVQTLFLLGEPNAQHPVWGSQGSDLASESAAQGDILQAAFQDSYRNLTLKTLSGLNWAEKHCPMARYVLKTDDDVYVNVPELVSELVLRGGRWGQWERSTEPQREAEQEGGQVLHSEEVPLLYLGRVHWRVNPSRTPGGRHRVSEEQWPHTWGPFPPYASGTGYVLSASAVQLILKVASRAPLLPLEDVFVGVSARRGGLAPTQCVKLAGATHYPLDRCCYGKFLLTSHRLDPWKMQEAWKLVGGSDGERTAPFCSWFQGVLGILRCRAIAWLQS
Protein Length full length protein
Tag Info The following tags are available.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Involved in GM1/GD1B/GA1 ganglioside biosynthesis.
Gene References into Functions
  1. Colorectal cancer (CRC) patients expressing both high B7-H3 and high B3GALT4 contributed to a significant decrease in overall survival. The expression of B3GALT4 in CRC is positively correlated with B7-H3 expression in vitro. B7-H3/B3GLAT4 may be used as dual prognostic biomarkers for CRC. PMID: 30131660
  2. Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function PMID: 21519903
  3. Data showed that GM1/GD1b/GA1 synthase transfectant cells had definite reduction in cell growth and invasion. PMID: 20594196
  4. We found beta3Gal-T4 and T5 enzymatic activity in ovarian cancer tissues, indicating that these enzymes are expressed at least in ovarian cancer PMID: 19225246
Subcellular Location Golgi apparatus membrane, Single-pass type II membrane protein
Protein Families Glycosyltransferase 31 family
Tissue Specificity Highly expressed in heart, skeletal muscle and pancreas and, to a lesser extent, in brain, placenta, kidney, liver and lung.
Database Links

HGNC: 919

OMIM: 603095

KEGG: hsa:8705

STRING: 9606.ENSP00000390784

UniGene: Hs.534375

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