Recombinant Human Brain protein I3 (BRI3)

Code CSB-CF002811HU
MSDS
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
BRI3
Uniprot No.
Alternative Names
BRI3; Brain protein I3; pRGR2
Species
Homo sapiens (Human)
Expression Region
1-125
Target Protein Sequence
MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIH SRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNC GATFA
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver.
Gene References into Functions
  1. In the context of hepatocellular carcinoma cells, BRI3 is a target of WNT signaling. PMID: 20538055
  2. An X-ray data set was collected to 1.6 A resolution using synchrotron radiation, of a ligandin recombinant fusion protein. PMID: 16508092
  3. Possible roles of BRI3 in the process of neuronal differentiation. PMID: 18452648
  4. BRI3 inhibits the various processing of amyloid protein precursor by blocking the access of alpha- and beta-secretases. PMID: 19366692
  5. BRI3 RNA is expressed less in stage 3 colon cancer in comparison to stage 2 colon cancer, and it is among 8 genes which can be used as a gene signature to differentiate colon cancer stages. PMID: 17390049

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Subcellular Location
Lysosome membrane; Multi-pass membrane protein.; [Isoform 1]: Cytoplasm, perinuclear region.; [Isoform 2]: Cytoplasm. Nucleus.
Protein Families
BRI3 family
Database Links

HGNC: 1109

OMIM: 615628

KEGG: hsa:25798

STRING: 9606.ENSP00000297290

UniGene: Hs.567438

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