Recombinant Human Cadherin-11 (CDH11)

Code CSB-CF005036HU
MSDS
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
CDH11
Uniprot No.
Alternative Names
CDH11; Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin
Species
Homo sapiens (Human)
Expression Region
54-796
Target Protein Sequence
GWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Gene References into Functions
  1. Elevated levels of PLAUR, a validated target gene, and CDH11 were confirmed in gastric tumors with low expression of miR-335. The 3'UTR of CDH11 was identified to be directly targeted by miR-335. PMID: 29075357
  2. This study reveals loss-of-function mutations in CDH11 as a probable cause of Elsahy-Waters syndrome phenotype. PMID: 28988429
  3. the observed CDH11 expression in active MM patients' peripheral blood was carried by circulating plasma cell clone(s), outgoing from an osteoblastic niche, conferring the disease transformation into symptomatic MM or its relapse. PMID: 27118219
  4. data show that ErbB2 and Akt are important for CNC migration and implicate other ErbB receptors and Akt-independent signaling pathways. Our findings provide the first example of a functional interaction between the extracellular domain of a type II classical cadherin and growth factor receptors PMID: 29190819
  5. Chemoresistant B-ALL patients are associated with increased methylation in ADAMTSL5 and CDH11. PMID: 28292214
  6. engagement of CDH11 through homophilic interactions, led to swift activation of the TGF-beta and ROCK pathways as evidenced by phosphorylation of downstream effectors. PMID: 27311482
  7. Cad-11 expression was significantly increased in pancreatic stellate cells and pancreatic cancer cells. PMID: 27855278
  8. Upregulation of miR-27b significantly accelerated the proliferation, cell cycle transition from G1 to S phase, migration and invasion of C33A cells, while downregulation of miR-27b suppressed the proliferation and invasion of HeLa cells PMID: 26706910
  9. observations suggest that clathrin-mediated internalization of Cad11 regulates surface trafficking of Cad11 and that dynamic turnover of Cad11 regulates the migratory function of Cad11 in prostate cancer cells. PMID: 26519476
  10. that U87-p75(NTR) cells express higher levels of Cdh-11 protein and that siRNA-mediated knockdown of Cdh-11 resulted in a significant decrease in p75(NTR)-mediated glioblastoma cell migration PMID: 26476273
  11. Invasive cancer cells had increased expression of mesenchymal markers cadherin 2 and 11 that localized with stromal cell cadherin 11, suggesting that these molecules are involved in stromal cell engraftment. PMID: 26046821
  12. Data suggest methylation status of gene promoters for CDH11 (cadherin 11) and BASP1 (brain abundant membrane attached signal protein 1) in tumor, skin, and metastatic tumor tissue may serve as prognostic biomarkers in patients with advanced melanoma. PMID: 25919928
  13. Cadherin-11 may be hyper-expressed in the peripheral blood of diffuse systemic scleroderma patients. PMID: 26121083
  14. Our results demonstrate that parathyroid hormone stimulates hematopoiesis through promoting the upregulation of CDH11 expression in bone marrow mesenchymal stromal cells PMID: 24648356
  15. High Cad-11 expression is associated with bone metastases of Ewing sarcoma. PMID: 26092671
  16. evidence for the involvement of CDH11 in Autism Spectrum Disorder which is consistent with the association of other cadherins with Autism Spectrum Disorder and neuropsychiatric diseases PMID: 24839052
  17. Cadherin 11, a miR-675 target, induces N-cadherin expression and epithelial-mesenchymal transition in melasma. PMID: 24940649
  18. This study evaluated the expression of CAD11 in the peripheral blood of rheumatoid arthritis patients and normal controls. PMID: 25173800
  19. High Cadherin-11 expression is associated with breast cancer. PMID: 24681547
  20. Data indicate that knockdown of CDH11 expression in primary human glioblastoma cells inhibits TGFbeta-stimulated migration. PMID: 23951053
  21. These data demonstrate that Cad-11 is a mediator of dermal fibrosis and TGFbeta production and suggest that Cad-11 may be a therapeutic target in systemic sclerosis. PMID: 24757152
  22. Data indicate that the interaction of mesenchymal stem cells (MSC) with fibroblast-like synoviocytes (FLS) via cadherin-11 may contribute to angiogenesis and chronic synovitis by enhancing the secretion of placental growth factor (PlGF). PMID: 24574497
  23. Thus, our results indicated abnormal expression of CD44V6, CDH11, and beta-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research. PMID: 23971040
  24. Results indicate the necessity of cadherin-11 for dystrophic calcific nodule formation, which proceeds through an Erk1/2-dependent pathway. PMID: 23162011
  25. The study of CDH11 5'-CpG island hypermethylation in primary tumours and lymph node metastases of cancer patients showed this epigenetic alteration to be significantly confined to the disseminated cells. PMID: 22374749
  26. Data indicate that CDH11 as a functional tumor suppressor and an important antagonist of Wnt/beta-catenin signaling, with frequent epigenetic inactivation in common carcinomas. PMID: 22139084
  27. These results show the functional significance of cadherin-11 expression in glioblastoma multiforme. PMID: 22267545
  28. CDH11 as a novel glioma invasion-associated candidate gene that likely contribute to the invasive phenotype of malignant gliomas. PMID: 21722156
  29. CDH11 expression was assessed in lung tissue from idiopathic pulmonary fibrosis patients. PMID: 21990376
  30. increased expression in patients with rheumatoid arthritis PMID: 21798287
  31. cad-11 modulates synovial fibroblasts to evoke inflammatory factors that may contribute to the inflammatory process in RA. PMID: 21536877
  32. suppression of MUC1 by miR-145 causes a reduction of beta-catenin as well as the oncogenic cadherin 11 PMID: 19996288
  33. The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation PMID: 11775026
  34. CADH11 was evaluated as a biomarker at the protein level and was found to have increased expression in xenograft tumors after S11248 treatment. PMID: 14985702
  35. A 2.62 Mbp minimal region of genomic loss of chromosome 16q22 was found in retinoblastoma which contains a hotspot CDH11, implicating CDH11as a potential tumor suppressor gene in retinoblastoma. PMID: 15383628
  36. primary aneurysmal bone cysts are mesenchymal neoplasms exhibiting USP6 and/or CDH11 oncogenic rearrangements PMID: 15509545
  37. Review. Cadherin-11 expression confers upon cells a fundamental change in cellular behavior. Its expression on fibroblast-like synoviocytes may determine their behavior & differentiation. PMID: 15743489
  38. Together, these studies implicate cadherin-11 in synovial tissue and lining layer formation and provide an in vitro system to model fibroblast-like synoviocyte behavior and function in organizing the synovial tissue. PMID: 16651616
  39. Cadherin-11 is involved in the intercellular physical coupling of detrusor smooth muscle bladder cells and also of myofibroblasts. PMID: 17292535
  40. Overexpression of osteoblast cadherin is associated with breast cancer cell metastatic potential PMID: 18193170
  41. The results indicate that CDH11 may be useful as a prognostic marker of disease progression and survival in osteosarcoma. PMID: 18359978
  42. cadherin-11 promotes homing and migration to bone and osteoclastogenesis through mediating the homophilic interactions of breast cancer cells with marrow stromal/osteoblastic cells, thereby enhancing bone metastases. PMID: 18575746
  43. These findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone. PMID: 18708358
  44. Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation PMID: 18821672
  45. Cadherin-11 and fascin might be useful markers for recurrence of pleomorphic adenomas. PMID: 19133007
  46. Cadherin-11 mRNA and protein levels are regulated by the activity of GSK3beta and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of the cadherin-11 3'UTR PMID: 19274078

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Involvement in disease
A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
Database Links

HGNC: 1750

OMIM: 600023

KEGG: hsa:1009

STRING: 9606.ENSP00000268603

UniGene: Hs.116471

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