CDH11 Antibody

Code CSB-PA005036ESR1HU
Size US$166
  • Western blot
    All lanes: CDH11 antibody at 6μg/ml + Jurkat whole cell lysate
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 88, 77 kDa
    Observed band size: 88 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005036ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA005036ESR1HU at dilution of 1:100

  • Immunoprecipitating CDH11 in SH-SY5Y whole cell lysate
    Lane 1: Rabbit control IgG instead of CSB-PA005036ESR1HU in SH-SY5Y whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/5000)
    Lane 2: CSB-PA005036ESR1HU (8μg) + SH-SY5Y whole cell lysate (500μg)
    Lane 3: SH-SY5Y whole cell lysate (20μg)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CDH11 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
CDH11; Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin
Raised in
Species Reactivity
Recombinant Human Cadherin-11 protein (637-796AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IP 1:200-1:2000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews
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Applications : Western blot

Sample type: cells

Review: the CDH11 protein exhibited notably higher expression in the metastatic OSCC tissues than in the non-metastatic OSCC tissues.

By Anonymous

Target Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Gene References into Functions
  1. Elevated levels of PLAUR, a validated target gene, and CDH11 were confirmed in gastric tumors with low expression of miR-335. The 3'UTR of CDH11 was identified to be directly targeted by miR-335. PMID: 29075357
  2. This study reveals loss-of-function mutations in CDH11 as a probable cause of Elsahy-Waters syndrome phenotype. PMID: 28988429
  3. the observed CDH11 expression in active MM patients' peripheral blood was carried by circulating plasma cell clone(s), outgoing from an osteoblastic niche, conferring the disease transformation into symptomatic MM or its relapse. PMID: 27118219
  4. data show that ErbB2 and Akt are important for CNC migration and implicate other ErbB receptors and Akt-independent signaling pathways. Our findings provide the first example of a functional interaction between the extracellular domain of a type II classical cadherin and growth factor receptors PMID: 29190819
  5. Chemoresistant B-ALL patients are associated with increased methylation in ADAMTSL5 and CDH11. PMID: 28292214
  6. engagement of CDH11 through homophilic interactions, led to swift activation of the TGF-beta and ROCK pathways as evidenced by phosphorylation of downstream effectors. PMID: 27311482
  7. Cad-11 expression was significantly increased in pancreatic stellate cells and pancreatic cancer cells. PMID: 27855278
  8. Upregulation of miR-27b significantly accelerated the proliferation, cell cycle transition from G1 to S phase, migration and invasion of C33A cells, while downregulation of miR-27b suppressed the proliferation and invasion of HeLa cells PMID: 26706910
  9. observations suggest that clathrin-mediated internalization of Cad11 regulates surface trafficking of Cad11 and that dynamic turnover of Cad11 regulates the migratory function of Cad11 in prostate cancer cells. PMID: 26519476
  10. that U87-p75(NTR) cells express higher levels of Cdh-11 protein and that siRNA-mediated knockdown of Cdh-11 resulted in a significant decrease in p75(NTR)-mediated glioblastoma cell migration PMID: 26476273
  11. Invasive cancer cells had increased expression of mesenchymal markers cadherin 2 and 11 that localized with stromal cell cadherin 11, suggesting that these molecules are involved in stromal cell engraftment. PMID: 26046821
  12. Data suggest methylation status of gene promoters for CDH11 (cadherin 11) and BASP1 (brain abundant membrane attached signal protein 1) in tumor, skin, and metastatic tumor tissue may serve as prognostic biomarkers in patients with advanced melanoma. PMID: 25919928
  13. Cadherin-11 may be hyper-expressed in the peripheral blood of diffuse systemic scleroderma patients. PMID: 26121083
  14. Our results demonstrate that parathyroid hormone stimulates hematopoiesis through promoting the upregulation of CDH11 expression in bone marrow mesenchymal stromal cells PMID: 24648356
  15. High Cad-11 expression is associated with bone metastases of Ewing sarcoma. PMID: 26092671
  16. evidence for the involvement of CDH11 in Autism Spectrum Disorder which is consistent with the association of other cadherins with Autism Spectrum Disorder and neuropsychiatric diseases PMID: 24839052
  17. Cadherin 11, a miR-675 target, induces N-cadherin expression and epithelial-mesenchymal transition in melasma. PMID: 24940649
  18. This study evaluated the expression of CAD11 in the peripheral blood of rheumatoid arthritis patients and normal controls. PMID: 25173800
  19. High Cadherin-11 expression is associated with breast cancer. PMID: 24681547
  20. Data indicate that knockdown of CDH11 expression in primary human glioblastoma cells inhibits TGFbeta-stimulated migration. PMID: 23951053
  21. These data demonstrate that Cad-11 is a mediator of dermal fibrosis and TGFbeta production and suggest that Cad-11 may be a therapeutic target in systemic sclerosis. PMID: 24757152
  22. Data indicate that the interaction of mesenchymal stem cells (MSC) with fibroblast-like synoviocytes (FLS) via cadherin-11 may contribute to angiogenesis and chronic synovitis by enhancing the secretion of placental growth factor (PlGF). PMID: 24574497
  23. Thus, our results indicated abnormal expression of CD44V6, CDH11, and beta-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research. PMID: 23971040
  24. Results indicate the necessity of cadherin-11 for dystrophic calcific nodule formation, which proceeds through an Erk1/2-dependent pathway. PMID: 23162011
  25. The study of CDH11 5'-CpG island hypermethylation in primary tumours and lymph node metastases of cancer patients showed this epigenetic alteration to be significantly confined to the disseminated cells. PMID: 22374749
  26. Data indicate that CDH11 as a functional tumor suppressor and an important antagonist of Wnt/beta-catenin signaling, with frequent epigenetic inactivation in common carcinomas. PMID: 22139084
  27. These results show the functional significance of cadherin-11 expression in glioblastoma multiforme. PMID: 22267545
  28. CDH11 as a novel glioma invasion-associated candidate gene that likely contribute to the invasive phenotype of malignant gliomas. PMID: 21722156
  29. CDH11 expression was assessed in lung tissue from idiopathic pulmonary fibrosis patients. PMID: 21990376
  30. increased expression in patients with rheumatoid arthritis PMID: 21798287
  31. cad-11 modulates synovial fibroblasts to evoke inflammatory factors that may contribute to the inflammatory process in RA. PMID: 21536877
  32. suppression of MUC1 by miR-145 causes a reduction of beta-catenin as well as the oncogenic cadherin 11 PMID: 19996288
  33. The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation PMID: 11775026
  34. CADH11 was evaluated as a biomarker at the protein level and was found to have increased expression in xenograft tumors after S11248 treatment. PMID: 14985702
  35. A 2.62 Mbp minimal region of genomic loss of chromosome 16q22 was found in retinoblastoma which contains a hotspot CDH11, implicating CDH11as a potential tumor suppressor gene in retinoblastoma. PMID: 15383628
  36. primary aneurysmal bone cysts are mesenchymal neoplasms exhibiting USP6 and/or CDH11 oncogenic rearrangements PMID: 15509545
  37. Review. Cadherin-11 expression confers upon cells a fundamental change in cellular behavior. Its expression on fibroblast-like synoviocytes may determine their behavior & differentiation. PMID: 15743489
  38. Together, these studies implicate cadherin-11 in synovial tissue and lining layer formation and provide an in vitro system to model fibroblast-like synoviocyte behavior and function in organizing the synovial tissue. PMID: 16651616
  39. Cadherin-11 is involved in the intercellular physical coupling of detrusor smooth muscle bladder cells and also of myofibroblasts. PMID: 17292535
  40. Overexpression of osteoblast cadherin is associated with breast cancer cell metastatic potential PMID: 18193170
  41. The results indicate that CDH11 may be useful as a prognostic marker of disease progression and survival in osteosarcoma. PMID: 18359978
  42. cadherin-11 promotes homing and migration to bone and osteoclastogenesis through mediating the homophilic interactions of breast cancer cells with marrow stromal/osteoblastic cells, thereby enhancing bone metastases. PMID: 18575746
  43. These findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone. PMID: 18708358
  44. Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation PMID: 18821672
  45. Cadherin-11 and fascin might be useful markers for recurrence of pleomorphic adenomas. PMID: 19133007
  46. Cadherin-11 mRNA and protein levels are regulated by the activity of GSK3beta and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of the cadherin-11 3'UTR PMID: 19274078

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Involvement in disease
A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
Database Links

HGNC: 1750

OMIM: 600023

KEGG: hsa:1009

STRING: 9606.ENSP00000268603

UniGene: Hs.116471

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