Recombinant Human Ceramide synthase 2 (CERS2)

1. As potential molecular markers for bladder carcinoma, both TWIST1 and LASS2 transcripts seem to play role during the tumorigenesis and development of bladder cancer. PMID: 30213291
2. Results show that silencing of ATP6V0C in highly metastatic prostate cancer (PC) cell lines, inhibited V-ATPase activity, which coincided with the inhibition of cell migration and invasion in vitro, as well as a marked decrease in the expression of LASS2/TMSG1 probably through positive feedback. PMID: 29138865
3. CerS2-knockdown via CRISPR-Cas9 technology in cultured colon epithelial cells impaired barrier function. PMID: 28699686
4. Low expression of LASS2 and TGFB1 contributes to the aggressiveness and poor prognosis of hepatocellular carcinoma, and may represent a novel prognostic biomarker for hepatocellular carcinoma patients. PMID: 27581744
5. ASGR1 can inhibit the activity of V-ATPase by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells. PMID: 27241665
6. These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths. PMID: 26887952
7. Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating expression of KLF4/LASS2/V-ATPase proteins in breast cancer. PMID: 26110566
8. these results indicate that miR-9 upregulation might be associated with malignant phenotype of bladder cancer. miR-9 promotes chemoresistance of bladder cancer cells by target LASS2. PMID: 26150338
9. Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion. PMID: 25213553
10. silencing of TMSG1 increased V-ATPase activity, decreased extracellular pH and in turn the activation of secreted MMP-2, which ultimately promoted metastasis capacity of breast cancer cell. PMID: 25973015
11. Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase-dependent mitochondrial pathway. PMID: 25735224
12. the vacuolar ATPase (V-ATPase) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1 PMID: 25501280
13. the inhibitory effect of the LASS2 on growth, invasion and metastasis of prostate cancer cells PMID: 24453046
14. Co-expression of CerS2 with CerS4/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation. PMID: 23538298
15. expression and role of ceramide synthase-2 in the lung PMID: 23690971
16. results contribute to the conclusion that LASS2/TMSG1 could regulate V-ATPase activity and intracellular pH through the direct interaction of its homeodomain and the C subunit of V-ATPase PMID: 22991218
17. LASS2 expression may be correlated with the development and progression of human bladder carcinoma PMID: 21755371
18. LASS2 is involved in chemotherapeutic outcomes and low LASS2 expression may predict chemoresistance. PMID: 22580606
19. Silencing of LASS2 can promote invasion of prostate cancer cells in vitro through the increase of V-ATPase activity, extracellular hydrogen ion concentration and activation of secreted MMP-2. PMID: 22178826
20. There is a nucleolar localization signal within TMSG-1. PMID: 22336162
21. silencing of LASS2/TMSG1 can promote invasion of prostate cancer cell in vitro through increase of V-ATPase activity which accelerated tumor's invasion and metastasis, indicating that LASS2/TMSG1 is a novel tumor metastasis suppressor gene PMID: 22573553
22. Interaction of KLF6 and Sp1, together with their binding of elements in exon 1 are critical events in initiation of transcription of the tmsg-1 gene. PMID: 21928351
23. KLF6 and Sp1 may participate in the inducible transcriptional regulation of TMSG-1 in prostate carcinoma cells. PMID: 22169644
24. TMSG-1 overexpression caused strong inhibition of proliferation and decreased clonogenicity of MDA-MB-231 cells, and promoted cell apoptosis. PMID: 18194600
25. Overexpression of CerS2 resulted in partial protection from ionizing radiation-induced apoptosis PMID: 20406683
26. CerS2 and CerS6 mRNA was significantly elevated in breast cancer tissue compared to paired normal tissue, with approximately half of the individuals showing elevated CerS2 and CerS6 mRNA. PMID: 19912991
27. activity of CerS2 can be regulated by another bioactive sphingolipid, sphingosine 1-phosphate PMID: 18165233
28. CerS2 down-regulation had a broad effect on ceramide homoeostasis, not just on very-long-chain ceramides. PMID: 19728861

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HGNC: 14076

OMIM: 606920

KEGG: hsa:29956

STRING: 9606.ENSP00000271688

UniGene: Hs.744017