Recombinant Human Ectonucleoside triphosphate diphosphohydrolase 6(ENTPD6)

Code CSB-CF007695HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O75354
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS
Source in vitro E.coli expression system
Gene Names ENTPD6
Protein Names Recommended name: Ectonucleoside triphosphate diphosphohydrolase 6 Short name= NTPDase 6 EC= 3.6.1.6 Alternative name(s): CD39 antigen-like 2
Expression Region 1-484
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity).
Subcellular Location Golgi apparatus membrane, Single-pass type II membrane protein, Secreted
Protein Families GDA1/CD39 NTPase family
Tissue Specificity Expressed in most tissues, but predominantly in heart.
Database Links

HGNC: 3368

OMIM: 603160

KEGG: hsa:955

STRING: 9606.ENSP00000365840

UniGene: Hs.500375

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