Recombinant Human Gamma-glutamyltranspeptidase 1(GGT1)

Code CSB-CF009394HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P19440
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG
Source in vitro E.coli expression system
Gene Names GGT1
Protein Names Recommended name: Gamma-glutamyltranspeptidase 1 Short name= GGT 1 EC= 2.3.2.2Alternative name(s): Gamma-glutamyltransferase 1 Glutathione hydrolase 1 EC= 3.4.19.13 CD_antigen= CD224Cleaved into the following 2 chains: 1. Gamma-glutamyltranspe
Expression Region 1-380
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.
Involvement in disease Glutathionuria (GLUTH)
Subcellular Location Cell membrane, Single-pass type II membrane protein
Protein Families Gamma-glutamyltransferase family
Tissue Specificity Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
Database Links

HGNC: 4250

OMIM: 231950

KEGG: hsa:2678

STRING: 9606.ENSP00000248923

UniGene: Hs.595809

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