Recombinant Human Immunoglobulin superfamily member 1(IGSF1)-VLPs

Code CSB-MP854051HU(A4)
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Product Details

Target Names
Uniprot No.
Research Area
Cell Biology
Alternative Names
IGSF1; IGDC1; KIAA0364; PGSF2; Immunoglobulin superfamily member 1; IgSF1; Immunoglobulin-like domain-containing protein 1; Inhibin-binding protein; InhBP; Pituitary gland-specific factor 2; p120
Homo sapiens (Human)
Mammalian cell
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Tag Info
C-terminal 10xHis-tagged
If you have specified tag type, please tell us and we will check if it’s possible to develop.
Lyophilized powder
Note: We will default ship it in lyophilized form with normal bule ice packs. However, if you request to ship in liquid form, it needs to be shipped with dry ice, please communicate with us in advance and extra fees for dry ice and dry ice box will be charged.
Lyophilized from PBS, 6% Trehalose, pH 7.4
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
Datasheet & COA
Please contact us to get it.

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Target Background

Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription.
Gene References into Functions
  1. A novel mutation (c.2713C>T, p.Q905X) of the IGSF1 gene was identified that causes congenital central hypothyroidism in a Japanese family. The findings further expand the clinical heterogeneity of this entity. PMID: 27762734
  2. We identified a novel insertion mutation in the IGSF1 gene and further delineated the phenotype of the IGSF1-deficiency syndrome. Our findings indicate a possible association between an IGSF1 mutation and neurological phenotypes. PMID: 27310681
  3. Individuals with identical IGSF1 deletions can exhibit variable pituitary hormone deficiencies, of which overt TSH deficiency is the most consistent feature PMID: 27146357
  4. IGSF1 Deficiency is associated with X-linked IGSF1 deficiency syndrome. PMID: 26840047
  5. Adult male patients with IGSF1 deficiency exhibit mild deficits in attentional control on formal testing. PMID: 26387489
  6. This case suggests that more attention should be paid to intrauterine growth and birth history when patients are suspected of having an IGSF1 mutation PMID: 26302767
  7. There is insufficient evidence to conclude that the three observed VUCSs in IGSF1 are associated with CDGP, making it unlikely that IGSF1 mutations are a prevalent cause of CDGP. PMID: 25354429
  8. Immunohistochemistry showed increased IGSF1 staining in the GH-producing tumor from the patient with the IGSF1 p.N604T variant compared with a GH-producing adenoma from a patient negative for any IGSF1 variants and with normal control pituitary tissue. PMID: 25527509
  9. Data suggest male subjects with IGSF1 deficiency syndrome exhibit X-linked congenital/central hypothyroidism, delayed puberty, macro-orchidism, hypoprolactinemia, metabolic syndrome, and transient partial growth hormone deficiency. [CASE REPORTS] PMID: 24108313
  10. Our findings provide additional genetic evidence that loss-of-function mutations in IGSF1 cause an X-linked form of C-CH and variable prolactin deficiency. PMID: 23966245
  11. Using exome and candidate gene sequencing, 8 distinct mutations and 2 deletions in IGSF1 were identified in males from 11 unrelated families with central hypothyroidism, testicular enlargement and variably low prolactin concentrations. PMID: 23143598
  12. IgSF1 is processed through sequential proteolysis by signal peptidase and signal peptide peptidase PMID: 18981173

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Involvement in disease
Hypothyroidism, central, and testicular enlargement (CHTE)
Subcellular Location
[Isoform 1]: Membrane; Multi-pass membrane protein.; [Isoform 2]: Membrane; Multi-pass membrane protein.; [Isoform 3]: Secreted.
Tissue Specificity
Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pit
Database Links

HGNC: 5948

OMIM: 300137

KEGG: hsa:3547

STRING: 9606.ENSP00000359940

UniGene: Hs.22111

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