Recombinant Human Leucine-rich repeat transmembrane protein FLRT2(FLRT2)

Code CSB-CF008730HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O43155
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence CPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT
Source in vitro E.coli expression system
Gene Names FLRT2
Protein Names Recommended name: Leucine-rich repeat transmembrane protein FLRT2 Alternative name(s): Fibronectin-like domain-containing leucine-rich transmembrane protein 2
Expression Region 36-660
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
Subcellular Location Cell membrane, Single-pass membrane protein, Endoplasmic reticulum membrane, Cell junction, focal adhesion, Secreted, extracellular space, extracellular matrix, Microsome membrane, Secreted, Cell junction, synapse, synaptosome
Tissue Specificity Expressed in pancreas, skeletal muscle, brain, and heart.
Database Links

HGNC: 3761

OMIM: 604807

KEGG: hsa:23768

STRING: 9606.ENSP00000332879

UniGene: Hs.533710

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