Polymeric immunoglobulin receptor
Short name= PIgR
Short name= Poly-Ig receptor
Hepatocellular carcinoma-associated protein TB6
Cleaved into the following chain:
1. Secretory component
Full Length of Mature Protein
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Secretory component: Secreted