Recombinant Human Potassium voltage-gated channel subfamily E member 1(KCNE1)

Code CSB-CF012025HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P15382
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Gene Names KCNE1
Protein Names Recommended name: Potassium voltage-gated channel subfamily E member 1 Alternative name(s): Delayed rectifier potassium channel subunit IsK IKs producing slow voltage-gated potassium channel subunit beta Mink Minimal potassium channel
Expression Region 1-129
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1
Involvement in disease Jervell and Lange-Nielsen syndrome 2 (JLNS2); Long QT syndrome 5 (LQT5)
Subcellular Location Cell membrane, Single-pass type I membrane protein, Apical cell membrane, Membrane raft
Protein Families Potassium channel KCNE family
Tissue Specificity Expressed in lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Expressed in the heart (PubMed:19219384). Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial
Database Links

HGNC: 6240

OMIM: 176261

KEGG: hsa:3753

STRING: 9606.ENSP00000337255

UniGene: Hs.121495

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