KCNE1 Antibody

Code CSB-PA012025GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. P15382
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Immunogen Human KCNE1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IF
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias potassium voltage-gated channel, Isk-related family, member 1;KCNE1;FLJ18426;FLJ38123;FLJ94103;ISK;JLNS;JLNS2;LQT2/5;LQT5;MGC33114;MinK ;
Immunogen Species Homo sapiens (Human)
Target Names KCNE1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
HGNC 6240
RGD 2956
MGI 96673
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Function Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1
Involvement in disease Jervell and Lange-Nielsen syndrome 2 (JLNS2); Long QT syndrome 5 (LQT5)
Subcellular Location Cell membrane, Single-pass type I membrane protein, Apical cell membrane, Membrane raft
Protein Families Potassium channel KCNE family
Tissue Specificity Expressed in lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Expressed in the heart (PubMed:19219384). Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial
Database Links

HGNC: 6240

OMIM: 176261

KEGG: hsa:3753

STRING: 9606.ENSP00000337255

UniGene: Hs.121495

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