Recombinant Human Prokineticin receptor 2 (PROKR2)

1. EG-VEGF and PROKR2 were highly expressed in colorectal primary lesions compared to positive controls. PROKR1 expression was lower and did not change in tumor specimens. PMID: 29226856
2. The deletion contained 17 protein coding genes including PROKR2 and BMP2, both of which are expressed during embryological development of the pituitary gland. PROKR2 mutations have been associated with hypopituitarism but a heterozygous deletion of this gene with hypopituitarism is a novel observation. PMID: 28586151
3. PROKR2 genetic mutation plays a role in the pathogenesis of pituitary stalk interruption syndrome. PMID: 28453858
4. a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL) (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population. PMID: 26984842
5. PROKR2 may play a role in susceptibility of pituitary stalk interruption syndrome PMID: 26956854
6. PROKR2 expression in human fetal ovary remained unchanged throughout gestation. PMID: 26192875
7. PKR2 protomers form type II dimers involving TMs 4 and 5, with a role for TM5 in modulation of PKR2 function. PMID: 25449422
8. PK2-induced PKR2 endocytosis is GRK2- and clathrin-dependent, but beta-arrestin-independent. PMID: 24509228
9. Wild-type PROKR2 activates different G-protein subtypes (Gq, Gs, and Gi/o) and recruits beta-arrestins. The effects of 9 missense mutations on these 2 processes showed that some mutations affected both or only one of them. PMID: 24830383
10. Single PROKR2 missense allelic variants can either affect both cAMP and IP signaling pathways differently or selectively. PMID: 24276467
11. Prokineticin (PK)1/PKR2-signalling pathway is involved in the regulation of the functional adequate capillarization in late pregnancy PMID: 23891065
12. TSHZ1 is a key regulator of mammalian olfactory bulb development and function and controls the expression of PROKR2. PMID: 24487590
13. V331M variant confers lower risk for recurrent miscarriage PMID: 23687280
14. An unexpectedly large prevalence of PROKR2 mutations was found in Kallmann syndrome patients from the Maghreb. PMID: 24031091
15. the distal region of the IL3 region of PROKR2 may differentially influence receptor trafficking and G-protein coupling PMID: 23969157
16. PROKR2 signaling does not directly affect Sertoli cell function in autosomal recessive Kallmann syndrome. PMID: 23200691
17. The role of PROKR2 in the etiology of congenital hypopituitarism, septo-optic dysplasia, and Kallmann syndrome is uncertain. PMID: 23386640
18. An ancient founder missense mutation in PROKR2 impairs human reproduction. PMID: 22773735
19. The R80C mutant of PROKR2 exerts a dominant negative effect on wild type PROKR2 by interfering with wild type receptor expression. PMID: 22745195
20. We report PROKR2 variants in congenital hypopituitarism with pituitary stalk interruption, suggesting a potential role of the prokineticin pathway in pituitary development. PMID: 22466334
21. hCG increases EG-VEGF, PROKR1 and PROKR2 mRNA and protein expression in a dose- and time-dependent manner, demonstrating a new role for hCG in the regulation of EG-VEGF and its receptors PMID: 22138749
22. genetic association studies in 103 patients from US and UK: Mutations in PROKR2, FGFR1, or FGF8 contributed to 7.8% of patients with combined pituitary hormone deficiency or septo-optic dysplasia. Data suggest genetic overlap with Kallmann syndrome. PMID: 22319038
23. The results suggest an identical transmembrane-bundle binding site for hPKR1 and hPKR2. PMID: 22132188
24. positive charges in the second intracellular loop mutations of the PKR2 receptor have roles in G-protein coupling and receptor trafficking PMID: 21454486
25. ligation of tubal TLR2 and activation of NFkappaB by C. trachomatis leads to increased tubal PROKR2, thereby predisposing the tubal microenvironment to ectopic implantation. PMID: 21224062
26. one tag SNP of PKR2 (rs6053283) was significantly associated with idiopathic recurrent pregnancy loss. PMID: 20847187
27. Patients with this genetic form of Kallmann syndrome have been reported to have a possible increased prevalence of obesity and sleep disorders, which may be related to the role of PROKR2 in food intake and circadian rhythms (Review) PMID: 20389090
28. PROKR2 may play a role in the pathophysiology of methamphetamine dependence in the Japanese population. PMID: 20576534
29. The functional characteristics of coronary endothelial cells depend on the expression of PKR1 and PKR2 levels and the divergent signaling pathways used by these receptors. PMID: 20023120
30. molecular cloning, amino acid sequence and expression in several human tissues PMID: 12427552
31. Two Kallmann syndrome patients presented a heterozygous T-to-G transversion in exon 2 (c.518T>G). PMID: 18723471
32. In Kallmann syndrome patients, ten different missense mutations have been identified in PROKR2. PMID: 18826963
33. Results suggest that PROKR2 may play a role in the pathophysiology of mood disorders in the Japanese population. PMID: 19544013

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HGNC: 15836

OMIM: 244200

KEGG: hsa:128674

STRING: 9606.ENSP00000217270

UniGene: Hs.375029