Recombinant Human Protein wntless homolog(WLS)

Code CSB-CF716359HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q5T9L3
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence VSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHME MSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKC TFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLV GIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINI PVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPI AVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQ VFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKW GGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTI THVDGPTEIYKLTRKEAQE
Source in vitro E.coli expression system
Gene Names WLS
Protein Names Recommended name: Protein wntless homolog Alternative name(s): Integral membrane protein GPR177 Protein evenness interrupted homolog Short name= EVI Putative NF-kappa-B-activating protein 373
Expression Region 43-541
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
Subcellular Location Golgi apparatus membrane, Multi-pass membrane protein, Cytoplasmic vesicle membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein, Endoplasmic reticulum membrane, Multi-pass membrane protein, Golgi apparatus membrane, Multi-pass membrane protein, Early endosome membrane, Multi-pass membrane protein
Protein Families Wntless family
Database Links

HGNC: 30238

OMIM: 611514

KEGG: hsa:79971

STRING: 9606.ENSP00000346829

UniGene: Hs.647659

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