Recombinant Human Uroplakin-3a(UPK3A)

Code CSB-CF025657HU
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names UPK3A
Uniprot No. O75631
Alternative Names UPK3A; UPK3; Uroplakin-3a; UP3a; Uroplakin III; UPIII
Species Homo sapiens (Human)
Expression Region 19-287
Target Protein Sequence VNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
Gene References into Functions
  1. High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer. PMID: 25743828
  2. High Uroplakin III expression is associated with bladder urothelial carcinoma from malignancy metastatic to the urinary bladder. PMID: 25368291
  3. a strong association between UPIII and in the group with tumor recurrence PMID: 24553301
  4. Loss of p63 expression is a prerequisite for uroplakin III expression in urothelial bladder cancer. PMID: 14654529
  5. Our results indicate that de novo mutations in UPIIIA can be involved in defective early kidney development, but probably constitute only a rare cause of human renal hypodysplasia in a minor subset of individuals [UPIIIA]. PMID: 16731295
  6. uroplakin III and III-delta4 genes were significantly up-regulated only in patients with nonulcerative interstitial cystitis PMID: 17698128
  7. Uroplakin III mRNA is up-regulated to a greater extent in vesicoureteral reflux than in control exfoliated urinary cells. PMID: 17880289
  8. Loss of UP III expression is associated with established markers of biologically aggressive bladder cancer PMID: 18313120
  9. Not a useful immunohistochemical marker for detection of pleural malignant mesothelioma. PMID: 18528285
  10. Uroplakin III plays a pivotal role in Eshcerichia coli UTI pathogenesis. PMID: 19007907
  11. studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli PMID: 19412341

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Involvement in disease Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
Subcellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein Families Uroplakin-3 family
Tissue Specificity Expressed in ureter.
Database Links

HGNC: 12580

OMIM: 611559

KEGG: hsa:7380

STRING: 9606.ENSP00000216211

UniGene: Hs.632787

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