UPK3A Antibody

Code CSB-PA025657ESR1HU
Size US$166
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  • Western blot
    All lanes: UPK3A antibody IgG at 1.76μg/ml + Mouse lung tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 31, 18 kDa
    Observed band size: 31 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UPK3A Polyclonal antibody
Uniprot No.
Target Names
UPK3A
Alternative Names
UPK3A; UPK3; Uroplakin-3a; UP3a; Uroplakin III; UPIII
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Uroplakin-3a protein (19-207AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
Gene References into Functions
  1. High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer. PMID: 25743828
  2. High Uroplakin III expression is associated with bladder urothelial carcinoma from malignancy metastatic to the urinary bladder. PMID: 25368291
  3. a strong association between UPIII and in the group with tumor recurrence PMID: 24553301
  4. Loss of p63 expression is a prerequisite for uroplakin III expression in urothelial bladder cancer. PMID: 14654529
  5. Our results indicate that de novo mutations in UPIIIA can be involved in defective early kidney development, but probably constitute only a rare cause of human renal hypodysplasia in a minor subset of individuals [UPIIIA]. PMID: 16731295
  6. uroplakin III and III-delta4 genes were significantly up-regulated only in patients with nonulcerative interstitial cystitis PMID: 17698128
  7. Uroplakin III mRNA is up-regulated to a greater extent in vesicoureteral reflux than in control exfoliated urinary cells. PMID: 17880289
  8. Loss of UP III expression is associated with established markers of biologically aggressive bladder cancer PMID: 18313120
  9. Not a useful immunohistochemical marker for detection of pleural malignant mesothelioma. PMID: 18528285
  10. Uroplakin III plays a pivotal role in Eshcerichia coli UTI pathogenesis. PMID: 19007907
  11. studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli PMID: 19412341

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Involvement in disease
Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein Families
Uroplakin-3 family
Tissue Specificity
Expressed in ureter.
Database Links

HGNC: 12580

OMIM: 611559

KEGG: hsa:7380

STRING: 9606.ENSP00000216211

UniGene: Hs.632787

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