Recombinant Mouse 5-hydroxytryptamine receptor 2A (Htr2a)

1. A pre- and post-synaptic distribution of 5-HT2aRs was found in hippocampus, related to facilitation of object memory. PMID: 27114257
2. these data demonstrate that sustained SERT loss of function reduces 5-HT2AR surface expression that is critical for the synergistic activation of alphaIIbbeta3 by 5-HT and ADP. PMID: 27422820
3. heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively. PMID: 28258217
4. In the present study we have demonstrated four new principal facts concerning the role of 5-HT2A receptors in thermoregulation PMID: 26621247
5. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. PMID: 26758213
6. Data indicate a role of presynaptic 5-hydroxytryptamine (serotonin) receptor 2A (5-HT2A receptor) located at thalamocortical synapses in the control of thalamofrontal connectivity and the associated cognitive functions. PMID: 26903620
7. Whole-brain mapping and pharmacological screening indicated that serotonin-2A receptor (Htr2a)-expressing cells in the central amygdala (CeA) control both innate and learned freezing, but in opposing directions PMID: 26590419
8. Hippocampal mRNA expression of Htr2a is decreased in serotonin deficient mice after early life stress. PMID: 25602134
9. Involvement of 5-HT2 receptors in the expression of withdrawal diarrhea in morphine-dependent mice PMID: 25034809
10. Elevated whole-blood 5HT or hyperserotonemia is a consistent finding in approximately 30% of autistic spectrum disorder individuals. PMID: 24894823
11. Translational and ecological study involving constitutive Htr2a(-/-) knock-out mice and related SNPs in depressed patients suggests that a lower neurotransmission at the 5-HT2AR may favor the susceptibility and severity of major depressive disorder PMID: 24801750
12. The results highlight a likely role of the 5-HT2 receptors in allergic airways disease and suggest that 5-HT2 receptor agonists may represent an effective and novel small molecule-based therapy for asthma. PMID: 25416380
13. Results of the current study suggest aggression displayed by TLX null and heterozygous mice involves 5-HT(2A/C) receptors. PMID: 23933143
14. the serotonin transporter has a role in regulating clearance of apoptotic cells through neuroendocrine signaling PMID: 24570000
15. Blockade of 5-HT2A receptors strengthens antidepressant effects of escitalopram by enhancing norepinephrine transmission. PMID: 23411676
16. These studies provide additional support for the link between 5-HT2A activation and hallucinogenesis. PMID: 23376711
17. The cortical population of 5-HT2A receptors mediate the locomotor-suppressing effects of clozapine. PMID: 22871913
18. 5-HT(2A) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex. PMID: 23508685
19. Augmented contractile properties of arteries in a model of type 2 diabetes mellitus are not due to changes in 5HT(2A)/5HT(2B) receptors. PMID: 23346101
20. Central administration of brain-derived neurotrophic factor leads to increase of 5-HT1A receptor gene expression but not 5-HT1A functional activity in mice genetically predisposed to beehavioral disorders. PMID: 22531372
21. Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A. PMID: 23129762
22. Data suggest that stimulation of 5HT2AR facilitates consolidation/extinction of fear memory and consolidation of object memory; blocking 5HT2AR impairs acquisition of fear memory extinction. Studies assume hippocampal/amygdala sites of action. PMID: 22722027
23. These findings provide a mechanism to explain the reduced sensitivity of Egr3(-/-) mice to the locomotor suppressive effects of second generation anti-psychotics. PMID: 22692564
24. Results suggested that 5-HT regulates epithelial proliferation and turnover. This regulation depended on neuronal rather than mucosal 5-HT. Serotonergic effects were linked to activation of 5-HT2A receptors on cholinergic submucosal neurons. PMID: 22609381
25. The results of the present study suggest that the 5-HT2Ar could participate in the hippocampal neurotransmission by acting on different neuronal populations. PMID: 22119732
26. Data suggest that Htr2a, serotonin, and signal transduction are important in mammary gland for induction of bone-regulating factors such as parathyroid hormone-related protein; results may apply in lactation and breast neoplasms. PMID: 22318950
27. The results of this study suggest a significant role of 5-HT(2A)R and 5-HT(2B)R in respiratory network modulation. PMID: 21789169
28. results indicate that 5-HT2ARs are crucial for MDMA-induced reinforcement and cue-induced reinstatement of MDMA-seeking behaviour. PMID: 20942998
29. The 5-HT2AR-metabotropic glutamate mGluR2 receptor (mGluR2) complex is necessary for the neuropsychological responses induced by hallucinogens. PMID: 21276828
30. Mice had high cortical 5-HT2A, but low 5-HT2C receptor densities. PMID: 21340474
31. Both 5-HT(2A) and 5-HT(2C) receptors modulate cortical dopamine efflux, but in opposite directions. PMID: 21118683
32. In frontal cortex of mice born to influenza virus-infected mothers, the 5-HT(2A) receptor is upregulated and the mGlu(2) receptor is downregulated, an alteration that may be involved in the behavioral changes observed. PMID: 21289196
33. Altered serotonin transporter and/or 5-HT1A receptor functionality in hippocampus could contribute to the relatively low sociability of the BTBR mouse strain. PMID: 21070242
34. Decreased 5-HT2A gene expression and 5-HT2A receptor functional activity was found in three investigated catalepsy prone mouse strains in comparison to catalepsy resistant AKR mice. PMID: 20345894
35. A bifurcation of the 5-HT2A receptor signaling pathway is neurotransmitter- and beta-arrestin2-dependent. PMID: 20926677
36. These observations point towards a direct association between amyloid-beta accumulation and changes in 5-HT2A receptor expression that is independent of upstream changes in the serotonergic system PMID: 20413853
37. 5-HT(2A) receptor may be functionally expressed to regulate mechanisms underlying osteoblast cell proliferation, at least in part, through activation of ERK/MAPK pathways in MC3T3-E1 cells. PMID: 20399747
38. We conclude that serotonergic connectivity was reproduced in vitro and that the serotonin neurite density is inhibited by chronic activation of the 5-HT(2) receptor. PMID: 19728996
39. activation involving disruption of a strong ionic interaction between helices 3 and 6 PMID: 11801601
40. was found on circular and longitudinal smooth muscle cells, neurons, enterocytes, and Paneth cells. PMID: 11960784
41. findings suggest that 5-HT2A/5-HT2C serotonin receptors may be involved in the neural control of male sexual motivation and arousal PMID: 12097814
42. Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in brainstem slices. PMID: 12486201
43. Knockout of serotonin transporter alters expression of 5-HT2A and 5-HT2C receptors in various brain regions; possible relation to altered knockout mouse behavior PMID: 12614326
44. intracellular trafficking of 5-HT2A receptors is regulated by PSD-95 PMID: 12682061
45. 5-HT(2A) receptors are strongly reduced in the frontal cortex, in the hippocampus, in the striatum and in the accumbens nucleus in socially isolated animals compared to group housed control mice. PMID: 12867255
46. The 5-HT2A receptor expressed in NIH3T3 cells can couple to PLA2 activation though a complex signaling mechanism involving both Galphai/o-associated Gbetagamma-mediated ERK1,2 activation and Galpha12/13-coupled, Rho-mediated p38 activation PMID: 12887695
47. The interaction of the 5-HT(2A) and the 5-HT(2C) receptor with specific sets of PDZ proteins may contribute to their different signal transduction properties PMID: 14988405
48. findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment PMID: 16873667
49. These results suggest that obesity increases hypothalamic 5-HT2A receptor gene expression, and pharmacologic inactivation of 5-HT2A receptors inhibits overfeeding and obesity in A(y) mice, but did not increase plasma adiponectin levels. PMID: 17097612
50. Interaction between 5-HT2 receptor activity in the dorsomedial medulla and CO(2) drive may elicit a cycle of hyperventilation with airway dilation and hypoventilation with airway narrowing PMID: 17537836

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KEGG: mmu:15558

STRING: 10090.ENSMUSP00000047774

UniGene: Mm.214351