Recombinant Mouse 5-hydroxytryptamine receptor 7 (Htr7)

1. Downregulation of the 5-HT7 receptor in the medial prefrontal cortex (mPFC) improves neonatal administration of phencyclidine-induced attentional deficits and impulsive-like overresponding and exacerbates compulsivity. These results suggest that 5-HT7R is involved in the cognitive outcomes of schizophrenia-like symptoms similar to humans. PMID: 29278697
2. The present study demonstrated that acute heroin administration resulted in robust disruptions in attention, impulsivity and motivation in mice. PMID: 29155092
3. The underlying molecular machinery involves 5-HT7R-mediated activation of MMP-9, which leads to CD44 cleavage followed by Cdc42 activation. PMID: 28564597
4. The results of this study provide evidence for the essential role of the 5HT7R in the acquisition of an allocentric strategy and in the ability to learn concomitantly both strategies. PMID: 27939340
5. The data of this study suggest that the 5-HT7R-mediated structural reorganization during the postnatal development might have a crucial role for the development and plasticity of forebrain areas such as cortex and striatum. PMID: 28122114
6. this study shows that 5-HT7 is expressed in the liver in vivo and in vitro in CCl4-induced damage, and that 5-HT7 receptor agonist but not the antagonist shows hepatoprotective effect against liver fibrosis PMID: 28043031
7. 5-HT7 is required for multiple actions of serotonin in the mammary glands. PMID: 25664318
8. Activation of HTR7 promoted opening of the ion channel TRPA1, which in turn triggered itch behaviors. Acute itch triggered by serotonin or a selective serotonin reuptake inhibitor required both HTR7 and TRPA1, as did development of atopic dermatitis. PMID: 26074006
9. Blockade of 5-HT7R Results in Increased Severity of Chronic DSS-induced Colitis. PMID: 25072499
10. data suggest that 5-HT7R tonically modulates cognitive processes involved in consolidation performances in object recognition. PMID: 23995300
11. These results indicate that 5-HT receptors are functionally expressed in a subpopulation of substantia gelatinosa neurons of the and activation of 5-HT receptors plays an important role in modulating orofacial nociceptive processing. PMID: 24516875
12. The results provide evidence that lurasidone can act as a 5-HT7 receptor antagonist and provide a possible explanation for its antidepressant effect. PMID: 23416039
13. Colitis severity was significantly lower in 5-HT7(-/-) mice. PMID: 23554310
14. 5-HT7 receptor functionally involved in the development of stress adaptation.[review] PMID: 23012886
15. Activation of the serotonin 5-HT7 receptor promotes synaptogenesis and enhances synaptic activity in hippocampal neurons at early postnatal stages. PMID: 22378867
16. 5-HT-induced hypothermia is mediated by the 5-HT(7) receptor PMID: 12529502
17. Binding sites consistent with mRNA distribution with highest densities found in anterior thalamic nuclei. PMID: 15026130
18. The results indicate an important role for the 5-HT(7) receptor in contextual hippocampal-dependent learning and suggest a possible neuronal correlate for such a role is present within the CA1 region of the hippocampus. PMID: 15078565
19. Data demonstrate distinct roles for 5-HT7R/G12 signaling pathways in neurite outgrowth and retraction PMID: 16120784
20. The results, with selective antagonists and knockout animals, provide compelling evidence of a specific contribution of 5-HT7 receptors to spinal locomotor rhythmogenesis in vivo. PMID: 16836640
21. The 5-HT7 receptor is of importance for behaviors affected by antidepressants; this suggests that the 5-HT7 receptor might be of relevance as a target for the treatment of obsessive-compulsive disorder. PMID: 17267119
22. Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain are reported. PMID: 18793707
23. 5-HT(7) receptor deletion augments the effect of various SSRIs on REM sleep suppression and this effect is distinct from those mediated via 5-HT(1A) receptors. PMID: 18948124
24. present study has shown that the 5-HT7 receptor is of importance for allocentric spatial memory PMID: 19447277
25. These results suggest that spinal 5-HT7 receptors are required for the production and coordination of 5-HT-induced locomotor-like activity in the neonatal mouse and are important for the coordination of voluntary locomotion in adult mice. PMID: 19458153

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KEGG: mmu:15566

STRING: 10090.ENSMUSP00000126847

UniGene: Mm.254266