Recombinant Mouse BDNF/NT-3 growth factors receptor (Ntrk2)

1. Low TRKB Expression is associated with social dominance. PMID: 30282736
2. We report here on the incorporation of a BDNF mimetic sequence into a supramolecular peptide amphiphile filamentous nanostructure capable of activating the BDNF receptor TrkB and downstream signaling in primary cortical neurons in vitro. PMID: 30211565
3. Data suggest that neurotrophic tyrosine receptor kinase type 2 (TrkB)-dependent neuronal differentiation is involved in the sustained antidepressant effects of ketamine. PMID: 29162814
4. increased BDNF-TrkB signaling and synaptogenesis in the nucleus accumbens by deletion of alpha7 nAChR plays a key role in depression PMID: 27821848
5. The changes in the expression patterns of proBDNF, BDNF, and their receptors under the influence of chronic alcohol consumption in the depressive ASC strain and nondepressive CBA strain mice are different. PMID: 28900083
6. A critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in the hippocampus and enhances depression-like behaviors later in life. PMID: 26503133
7. Ventral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavior otherwise facilitated by developmental stress hormone exposure. PMID: 29186135
8. BDNF acts retrogradely on TrkB in climbing fibers , and facilitates elimination of climbing fibers synapses from Purkinje cells somata during the third postnatal week. PMID: 28775326
9. The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings. PMID: 27339059
10. Signaling through postsynaptic trkB receptors is considered to be an essential part of a cellular mechanism for maintaining the contacts of some, but not all, synaptic contacts onto motoneurons PMID: 27433358
11. findings show that BDNF-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc. Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF-TrkB signaling as a pathologic mechanism during periods of chronic stress. PMID: 26858215
12. inhibition of Sig-1 R prevented cocaine-induced TrkB activation in hippocampal neurons. PMID: 27735948
13. After spinal cord injury, astrocyte-specific TrkB knock-out mice showed reduced hyperpathic responses and improved motor coordination. PMID: 28270575
14. Results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the brain-derived neurotrophic factor -ERK1/2-cAMP response element-binding protein pathway through tropomyosin receptor kinase B activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits. PMID: 27470063
15. Data show that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB receptor axonal anterograde transport. PMID: 28259553
16. findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR-CaMKII-dependent BDNF release from stimulated dendritic spines and subsequent TrkB activation on these same spines that is crucial for structural and functional plasticity PMID: 27680698
17. Following ethanol administration, phosphorylation of TrkB in the striatum was significantly reduced in wild-type mice. PMID: 26992697
18. Results suggest that the therapeutic actions of atypical antidepressant drugs involve various neurocircuits, some of which, but not all, appears to involve BDNF/TrkB and downstream neuroplastic signaling PMID: 26653128
19. Observations provide evidence that female-specific induction of estrogen receptor alpha expression confers neuroprotection with TrkB agonist therapy via Src family kinase activation and account for improved functional outcomes in female neonates post-hypoxia and ischemia. PMID: 26839918
20. data suggest antidepressant effects of BDNF-TrkB in the NAc, which could not be explained by activation of the transcription factors CREB or beta-catenin. The effects TrkB has on depression-related behavior in different brain regions appear to critically depend on the targeted cell type. PMID: 26315459
21. Study indicates that diminished mature BDNF trophic signaling through the TrkB receptor, rather than an induction in proBDNF, is a main contributing factor to the vulnerability of striatal neurons in the zQ175 HD mouse model PMID: 26282324
22. TrkB is an endothelial injury-response molecule in atherogenesis. Endothelial brain-derived neurotrophic factor/TrkB signaling reduces VE-cadherin shedding and protects against atherosclerotic lesion development in ApoE-/- mice. PMID: 26431274
23. Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and gamma-secretases. PMID: 26712630
24. Brain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), have a role the in pathophysiology of depression. PMID: 26506052
25. Expression of the dominant-negative BDNF receptor TrkB receptor in the majority of pyramidal neurons in adult visual cortex has strikingly different effects on cortical wiring than expression of the same transgene in a sparse neuron population. PMID: 25316336
26. The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2. PMID: 26574547
27. Glial TrkB signaling plays an important role in the early stage of neural protection after traumatic injury. PMID: 26476348
28. Demonstrate that TrkB protects endothelial integrity during atherogenesis by promoting Ets1-mediated VE-cadherin expression and plays a previously unknown protective role in the development of coronary artery disease. PMID: 25633318
29. activation of muscular TrkB by the BDNF mimetic, 7,8-dihydroxyflavone (7,8-DHF), is sufficient to protect the development of diet-induced obesity in female mice PMID: 25754472
30. Ntrk2 plays a role in the pathologic remodeling of the spleen that accompanies chronic Leishmania donovani infection. PMID: 25710496
31. SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through hippocampal BDNFB-TrkB pathway. PMID: 25522427
32. loss of memory and hippocampal synaptic plasticity in Parkinson disease models via BDNF/TrkB pathway. PMID: 25560396
33. Reduced TrkB does not affect beta-amyloidosis but exacerbates the manifestation of hippocampal mnemonic and signaling dysfunctions in early Alzheimer's disease. PMID: 25942043
34. Report a novel signaling mechanism in the heart that is activated by BDNF and provide evidence for a global role of this neurotrophin in the homeostasis of the organism by signaling through different TrkB receptor isoforms. PMID: 26347138
35. Slitrk5 modulates brain-derived neurotrophic factor (BDNF)-dependent biological responses through direct interaction with TrkB receptors. Under basal conditions, Slitrk5 interacts with a transsynaptic binding partner, protein tyrosine phosphatase delta. PMID: 26004511
36. This study demonistrated that selective impairment in extinction consolidation in male but not female TrkBfl/+:PV-Cre mice. PMID: 25127683
37. TrkB knockout mice display impaired cardiac contraction and relaxation, showing that BDNF/TrkB signaling acts constitutively to sustain in vivo myocardial performance. PMID: 25583515
38. Data indicate an important role of TRKB receptor in the pathogenesis of mastocytosis. PMID: 25124786
39. BDNF/TrkB signaling plays an important role in the NRG1-stimulated NR2B regulation. PMID: 25052836
40. a novel role for the TrkB.T1 receptor in sleep expression and provide new insights into the relationship between Brain-derived neurotrophic factor, psychiatric illness, and sleep PMID: 25502751
41. PTP1B is a novel physiological regulator of TrkB and enhanced BDNF/TrkB signaling may contribute to the beneficial metabolic effects of PTP1B deficiency PMID: 25288805
42. SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. PMID: 23977241
43. TrkB signaling in D1 neurons regulates body weight by distinct mechanisms for chow and high fat diet and may be important for defending the body against the development of obesity and obesity-related disorders. PMID: 23512795
44. These results suggest an important role for BDNF in regulating migration of TrkB-expressing pericytes/SMCs to promote cardiac blood vessel ensheathment and functional integrity during development. PMID: 24498100
45. Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. PMID: 24386206
46. Hypoxia-inducible factor-1 directly regulated TrkB expression, and, in turn, TrkB activated Akt signaling in metastatic lung cancer cells. PMID: 24982195
47. Gonadotropin surge promotes oocyte survival at the onset of reproductive cyclicity by inducing oocyte expression of NTRK2 full-length receptors that set in motion an AKT-mediated survival pathway PMID: 24877631
48. Our findings suggested essential autocrine/paracrine roles of the BDNF/TrkB signaling system in choriocarcinoma invasion and metastasis. PMID: 24403258
49. The data point to a set of behaviors and changes in gene expression following postnatal deletion of TrkB in the dorsal striatum distinct from those in other brain regions. PMID: 24369067
50. ability of 5-HT to induce the production of ROS resulting in transactivation of both PDGFbeta and TrkB receptors PMID: 24086766

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KEGG: mmu:18212

STRING: 10090.ENSMUSP00000078757

UniGene: Mm.130054