Recombinant Mouse C3a anaphylatoxin chemotactic receptor (C3ar1)

1. Development of burn-induced mechanical allodynia, thermal allodynia, weight bearing changes and edema was assessed in C3aR(-/-), C5aR1(-/-) and C5aR2(-/-) mice and compared to their wild type controls over three days. Burn-induced mechanical allodynia, thermal allodynia and weight bearing changes developed normally C3aR(-/-), C5aR1(-/-) and C5aR2(-/-) mice. PMID: 29274925
2. Complement component 3a receptor 1 role in the lung cancer progression. PMID: 29118090
3. The complement 3a receptor (C3aR1) participates in microglial signaling under pathological conditions and was recently shown to be activated by the neuropeptide TLQP-21. PMID: 28850719
4. whilst the C3aR modulates some elements of disease pathogenesis, overall it is not critical in effector responses and glomerular injury caused by autoimmunity to MPO PMID: 29315316
5. study provided detailed insights into the C3aR expression pattern in immune and stromal cells under steady-state conditions PMID: 28626064
6. proposal that C3aR activation alters the tumor inflammatory milieu, thereby promoting tumor growth PMID: 27183625
7. increased circulating lipopolysaccharide induces upregulation of complement C3a receptor on neutrophils and activation of the complement cascade. PMID: 26996437
8. showed that C3a receptor/C5a receptor-deficient mice developed much less severe uveitis than did control mice using all retinal examination methods PMID: 26394814
9. these findings suggest a critical role for C3a through autocrine/paracrine induction of C3aR in the pathogenesis of cigarette smoke-induced sterile inflammation and provide new therapeutic targets for the treatment of emphysema. PMID: 25465103
10. C3a/C3aR signaling during host immune response suppresses Fas expression and caspase-3 activity while increasing Bcl-2 proto-oncogene protein expression, providing protection to myeloid and lymphoid cells against L. monocytogenes-induced apoptosis. PMID: 24981453
11. This study indicated that C3a and C5a-mediated functions are not critical to the development of experimental autoimmune uveitis. PMID: 24035596
12. The binding of TLQP-21 to C3AR1 not only has effects on signaling but also modulates cellular functions PMID: 23940034
13. C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation. PMID: 23684067
14. The role of the anaphylatoxin C3a receptor in acute dextran sulfate sodium-induced colitis in mice, was investigated. PMID: 23638016
15. The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. PMID: 23696668
16. nT reg cells express C3aR and C5aR, and signaling through these receptors inhibits nT reg cell function. PMID: 23382542
17. Absence of signaling into CD4 cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3+ regulatory T cells. PMID: 23263555
18. Complement C3a receptor activation contributes to the pathogenesis of preeclampsia. PMID: 22868393
19. Clinical disease activity in C3aR(-/-), C5aR(-/-), and C6-deficient (C6-def) mice was decreased by 52, 94, and 65%, respectively, as compared with wild-type mice. PMID: 22205026
20. might participate in conjunction with other complement effector functions down-stream of C3/C3b in the protection of Th2 induced allergic contact dermatitis PMID: 22151392
21. distinct roles of C3a and C5a receptor signaling in complement-induced tubulointerstitial injury PMID: 21677637
22. These results confirm an important role for C5 cleavage in murine MI/R injury. PMID: 20930931
23. C3a plays an important role in CNS lupus, signaling through its receptor C3aR. PMID: 19900981
24. It remains unclear how the changes in these disease parameters contribute to the loss of the protective effect seen in C3aR(-/-) mice, however our data indicate a level of cross-modulation between the C3aR and C5aR during EAE. PMID: 19850104
25. This increased expression at late time points after occlusion is most likely the result of massive infiltration of leukocytes expressing the receptors. PMID: 11948810
26. The complement anaphylatoxin C3a receptor plays a novel regulatory role in the development of Th2 responses in a mouse model of pulmonary allergy. PMID: 12421977
27. The C3a-C3aR axis may prevent an uncontrolled release of hematopoietic stem cells into peripheral blood from bone marrow PMID: 14604969
28. C3a receptor mRNA is expressed in murine cortical and glomerular epithelium and renal medulla. PMID: 15356170
29. Deletion of the C3a receptor is protective in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in C57BL/6 mice. PMID: 15383607
30. Data demonstrate that independently of antibody production, absence of complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa despite a diminished inflammatory response in a mouse model of pneumonia. PMID: 16461429
31. These results indicate that C5 plays a crucial role in modulating the enhanced-respiratory syncytial virus disease phenotype, by affecting expression of C3aR in the lungs. PMID: 17079327
32. engagement of C3aR on the surface of dendritic cells leads to alterations in the level of intracellular cAMP. C3aR activation-induced depression of cAMP was associated with enhanced capacity of DCs for antigen uptake and T-cell stimulation PMID: 18812470
33. Activation of the C3aR plays a protective, not pathologic, role in the early phase of inflammatory nephritis in the MRL/lpr model of systemic lupus erythematosus. PMID: 19167760
34. C3aR in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance PMID: 19581423

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KEGG: mmu:12267

STRING: 10090.ENSMUSP00000048092

UniGene: Mm.2408