Recombinant Mouse Cysteinyl leukotriene receptor 1 (Cysltr1)

1. Montelukast also served a protective role in a murine ovariectomy (OVX) and unloadinginduced bone loss model. Altogether, these results confirmed that the CysLTR1 antagonist exerted an inhibitory effect on OC formation in vitro and in vivo. It may be useful for the treatment of bone diseases associated with excessive bone resorption. PMID: 29916540
2. The study presents a genetic approach in a colitis-associated colon cancer model further supporting an important role for CysLT1R signaling in colon tumorigenesis, driving immune mediators to promote immune cell infiltration in tumors. PMID: 28410235
3. Mechanistically, the effect of montelukast on osteoblastic differentiation acted by activating the extracellular regulated protein kinases (ERK) pathway. The obtained results suggested that montelukast promotes proliferation and differentiation in osteoblasts exposed to overload mechanics. PMID: 29032198
4. this study shows that CysLT1R-deficient mice that were exposed to chlorine demonstrated airway hyperresponsiveness to inhaled methacholine significantly greater than in wild-type BALB/c mice PMID: 27226094
5. The important role that CysLTR1 plays in colorectal cancer and intestinal polyps development. PMID: 26979937
6. Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3 PMID: 26255103
7. Involvement of CysLT1R in a model of asthma. PMID: 25477712
8. Suggest that myogenic tone is determined by AT1 and CysLT1 receptors acting together as mechanosensors via Gq/11-protein activation. PMID: 25395620
9. It plays a critical role in Ab1e42-induced neurotoxicity. PMID: 24269024
10. The CysLT(1) and CysLT(2) receptors were primarily localized in neurons, microglia and neutrophils PMID: 23132680
11. CysLT1R mediates LTD4-induced activation of microglial cells. PMID: 24141567
12. In an animal model of cognition impairment, CysLT1 receptor signaling is identified as proinflammatory and proamyloidogenic. PMID: 22982445
13. a single mutation of Thr151Gly in the 2nd inner loop of sysLT1 had a slight inhibitory effect on the desensitization. PMID: 23485744
14. present novel data that CysLT1R is expressed on ILC2s and LTD potently induces CysLT1R-dependent ILC2 production of IL-4, IL-5, and IL-13 PMID: 23688412
15. CysLT1R, CysLT2R and GPR17 might be involved in the MPTP-induced Parkinson disease damage in mice. PMID: 23505108
16. leukotriene D(4) recepter may be involved in the development of seizures in mice. PMID: 21641195
17. Rotenone induced an increased expression of CysLT(1) receptor in BV2 microglial cells. PMID: 21488207
18. Cysltr1-deficient C57BL/6 mice are protected from pulmonary inflammation both in active house dust mite sensitization and challenge, revealing a broad and dose-related role for CysLT1R in antigen presentation and downstream responses. PMID: 20574000
19. These findings provide evidence for a role for CysLTRs in bone marrow cells in transducing cytokine regulatory signals. PMID: 20219953
20. determination of role in enhanced vascular permeability of mice undergoing acute inflammatory responses PMID: 11932261
21. Targeted disruption of the CysLT(1) receptor significantly increases both the concentration of cys-LTs in the bronchoalveolar lavage fluid and the magnitude of septal thickening in the lung. PMID: 14970333
22. The type 1 cysteinyl leukotriene receptor (CysLT1) is involved in the recruitment of activated alpha beta and gamma delta T cells to inflamed tissues. PMID: 16002666
23. findings show that CysLT1 receptor attenuates while CysLT2 receptor facilitates oxygen glucose deprivation -induced PC12 cell death PMID: 16756959
24. Data show that cysteinyl leukotriene receptor 1 modulates cryoinjury in mice at least partly, and postinjury treatment with its antagonist pranlukast exerts the protective effect with a therapeutic window of 30 min. PMID: 17588329
25. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. PMID: 17693579
26. cysteinyl leukotriene type 1 receptor acts as a negative regulator of chondrocyte proliferation, with important and previously unrecognized implications for both fracture repair, and in a broader context, systemic chondrocyte growth and differentiation PMID: 19544365

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KEGG: mmu:58861

STRING: 10090.ENSMUSP00000063520

UniGene: Mm.287166